IL-12-secreting CAR-T cells reprogram the tumor microenvironment and…
Engineering CAR-T cells to release IL-12 shows promise for overcoming glioblastoma's notorious resistance, addressing a major barrier that has limited this therapy in solid tumors.
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Targeted inhibition of Nrf2 potentiates antitumor immunity and…
Blocking Nrf2 combined with immunotherapy enhances tumor control in hepatocellular carcinoma, suggesting a practical combination strategy for a cancer with few treatment options.
Novel or significantly improved treatmentMazdutide 9 mg in Chinese adults with a body mass index ≥30 kg/m² but…
A higher-dose dual GLP-1/glucagon agonist shows weight-reduction benefits in Chinese adults with obesity, expanding evidence beyond Western populations and approved doses.
Early cancer detection or preventionAdvancements in nanobiosensors for early cancer detection,…
Nanobiosensors for early cancer detection are advancing across multiple technologies, though clinical validation work remains substantial before widespread use.
Early cancer detection or preventionMPCI: A novel metric for quantifying DNA methylation patterns in NGS data.
A new computational method better captures epigenetic patterns in cancer DNA from blood, potentially improving how sensitive liquid biopsies detect disease.