📅 PUBMED DAILY TRIAGE — 2026-10-22 Window: 2026-10-21T09:00:00Z → 2026-10-22T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: 54 (59 unique PMIDs, 5 excluded by pub type) | Candidates evaluated: 0 High priority: 3 | Standard: 22 | Low/archive: 0 | Unsolicited finds: 2 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID42902584 · Calreticulin and myeloproliferative neoplasms: linking biology to targeted thera · 8/10 · CALR-targeted therapies for MPN represent a paradigm shift toward clonal elimination
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID42902385 · Epigenetic modulation of NKG2D ligands enhances NKG2D-CAR T cell efficacy in neu · 7/10 · Novel combinatorial strategy combining epigenetic ligand upregulation with NKG2D-CAR T cells for high-risk pediatric neu
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
PMID42902597 · Oral Versus Injectable Incretin-Based Anti-Obesity Therapies: An Integrated Comp · 8/10 · Orforglipron as the first oral non-peptide GLP-1RA completing phase 3 represents a transformative advance in cardiometab
Topics with no HIGH-priority finds today: • Early cancer detection (liquid biopsy, ctDNA, cfDNA): No HIGH today (best candidate scored 7/10 — PMID42902381) • AI/ML in clinical diagnostics and imaging: No HIGH today (best candidate scored 7/10 — PMID42902311) • Precision oncology and genomic medicine: No HIGH today (best candidate scored 6/10 — PMID42902370) • Aging, longevity, and population health: No HIGH today (best candidate scored 6/10 — PMID42902202) • Rare diseases with high unmet need: No candidates today (zero results)
🟢⚪ STANDARD (5–7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID42902412 · Nanoengineered STING agonists for cancer therapy: toward immunodynamic cont · 7/10 · Treatment Innovation PMID42902101 · Long-term hydroxyurea therapy alters bone marrow megakaryocyte morphology a · 6/10 · Diagnostics PMID42902386 · Ribosome biogenesis and selective translational control as oncogenic vulner · 6/10 · Drug Development PMID42902416 · Cardiac magnetic resonance with myocardial strain as a predictor of anthrac · 6/10 · Diagnostics PMID42902445 · In a Nutshell: Immune alterations in classic Hodgkin lymphoma. · 5/10 · Treatment Innovation
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
PMID42902381 · Comparative validation and local adaptation of gastric cancer risk assessme · 7/10 · Early Detection PMID42902395 · Profiling protein post-translational modifications in plasma-derived extrac · 7/10 · Genomics/Precision Medicine
AI/ML in clinical diagnostics and imaging
PMID42902311 · Preoperative prediction of positive margins in breast-conserving surgery us · 7/10 · Diagnostics PMID42902382 · Interpretable machine learning model for brain metastasis in breast cancer: · 7/10 · Diagnostics PMID42902265 · Integrated proteomics and machine learning reveal AHNAK as a discriminative · 7/10 · Diagnostics PMID42902096 · Opportunities and challenges of artificial intelligence and digital patholo · 6/10 · Diagnostics
Precision oncology and genomic medicine
PMID42902370 · Spatial multi-omics analyses of the tumor immune microenvironment: advances · 6/10 · Treatment Innovation
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID42902603 · Study protocol of a prospective, non-interventional cohort study evaluating · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
PMID42902526 · Bipolar Disorder and the Risk of Cardiovascular Diseases: A Systematic Revi · 7/10 · Public Health PMID42902215 · Clinical similarity, economic divergence: cost-effectiveness and population · 7/10 · Treatment Innovation PMID42902413 · Diagnostic accuracy of glycated albumin and fructosamine for detecting diab · 6/10 · Diagnostics PMID42902143 · Association of the remnant cholesterol inflammatory index and frailty with · 5/10 · Prevention
Aging, longevity, and population health
PMID42902202 · Association of adverse childhood experiences patterns with successful aging · 6/10 · Public Health PMID42902221 · Associations between comorbidities and survival outcomes in older adults wi · 6/10 · Public Health PMID42902099 · H3K9me3 inhibition reverses Alzheimer's progression by restoring synaptic a · 5/10 · Drug Development
💡 UNSOLICITED FINDS
PMID42902572 · Proenkephalin A and Heterogeneity of Hydrocortisone Treatment Effect in Septic S · 7/10 · Treatment Innovation · 🟢 NEAR_TERM_IMPLEMENTABLE — Near-term implementable finding → PENK ≥89 pmol/L independently predicts 28-day mortality (OR 3.24; 95% CI 1.62–6.74) and significantly interacts with hyd PMID42902254 · Outcome measures and monitoring framework in juvenile systemic sclerosis: bridgi · 5/10 · Other · 🟡 UNDERSERVED_POPULATION — Underserved or high-risk populations → A standardized monitoring framework for juvenile systemic sclerosis is proposed to align routine clinical assessment wit
📊 TODAY'S BREAKDOWN
By research category: • Treatment Innovation: 8 • Diagnostics: 7 • Drug Development: 3 • Public Health: 3 • Early Detection: 1 • Genomics/Precision Medicine: 1 • Prevention: 1 • Other: 1
By evidence maturity: • Exploratory: 17 • Validated: 8
By watchlist topic (reviewed / retained / highest score): • Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 9 reviewed / 6 kept / best 8/10 • CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / best 0/10 • Early cancer detection (liquid biopsy, ctDNA, cfDNA): 12 reviewed / 2 kept / best 7/10 • AI/ML in clinical diagnostics and imaging: 10 reviewed / 5 kept / best 7/10 • Precision oncology and genomic medicine: 1 reviewed / 1 kept / best 7/10 • Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 7 reviewed / 5 kept / best 8/10 • Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 8 reviewed / 8 kept / best 8/10 • Aging, longevity, and population health: 12 reviewed / 6 kept / best 6/10 • Rare diseases with high unmet need: 0 reviewed / 0 kept / best 0/10 • Sentinel scan: 10 reviewed / 2 kept / best 7/10
By source type: peer_reviewed 25 | preprint 0
Topics with zero 8+ articles this run: Early cancer detection, AI/ML in clinical diagnostics and imaging, Precision oncology and genomic medicine, Aging, longevity, and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- Window expansion: NOT triggered (>5 relevant records found)
- T2 (CBC/ML hematology): both primary and fallback queries returned 0 results; complete zero coverage, no fallback articles
- T9 (Rare diseases): zero results today; 42902254 (juvenile systemic sclerosis) captured via sentinel scan as unsolicited find
- T3 (Early cancer detection): ~50% false-positive rate via broad 'early detection' term; only 2 genuine T3 matches (42902381, 42902326)
- T4 (AI/ML diagnostics): 3 off-topic false positives (dental/sports applications) filtered; 5 genuine T4 articles retained
- 59 unique PMIDs retrieved; 5 excluded by publication type (2 Letters, 1 News, 2 Case Reports)
- EFetch abstracts for 25 priority articles; remaining 29 classified from ESummary metadata with appropriately reduced confidence
- All 10 topic searches completed; SUCCESS status confirmed
- Attempt 1 of 3 for 2026-10-22