Daily digest · Mon · 19 Oct 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

PMID 42893828 · Talquetamab and Its Effect on Relapsed and Refractory Multiple Myeloma. · 9/10 · Treatment Innovation
PMID 42893571 · Dual Metabolic Inhibition Via Vanadium-NO Synergistic Nanoplatform Potentiates Cancer Immunotherapy. · 9/10 · Treatment Innovation
PMID 42893057 · A novel multiplex digital PCR assay for simultaneous quantification of androgen receptor amplification, mutations, and splice variants in cell-free nucleic acids from metastatic castration-resistant prostate cancer. · 9/10 · Early Detection
PMID 42893843 · Surgical Treatment of Tumor-Induced Osteomalacia With Causative Tumors Affecting the Long Bones. · 8/10 · Genomics/Precision Medicine
PMID 42893825 · Impact of Physical Activity on Cardiovascular Outcomes in Metabolic Dysfunction-Associated Steatotic Liver Disease. · 8/10 · Public Health
PMID 42893742 · Sociocultural Determinants of Hepatocellular Carcinoma Prevention Behaviors Among Non-Hispanic Black and Hispanic Adults in the United States. · 8/10 · Early Detection
PMID 42893702 · Network Analysis of Chronic Disease Diagnosis Co-documentation in Insurance Claims Among Older Arkansans. · 8/10 · Public Health
PMID 42893696 · Characterization of the morphological, immunophenotypical and cytogenetic features of high-grade B-cell lymphoma with 11q aberration. · 8/10 · Diagnostics
PMID 42893681 · Prevalence, risk factors, and lived experiences of insomnia among cancer caregivers: A mixed-method study. · 8/10 · Early Detection
PMID 42893629 · Multi-omics liquid biopsy for leptomeningeal metastases in lung cancer: from molecular mechanisms to precision diagnosis and treatment. · 8/10 · Early Detection
PMID 42893626 · Hierarchical visual prompt disentanglement for continual rare disease diagnosis. · 8/10 · Genomics/Precision Medicine
PMID 42893493 · Nationwide prevalence of high-risk human papillomavirus and cervical cytology findings in Chile: a registry-based study (2019-2024). · 8/10 · Early Detection
PMID 42893475 · Therapeutic Peptide-Programmed Liquid-Crystalline Topology Switching for pH-Gated Postoperative Cancer Immunotherapy. · 8/10 · Treatment Innovation
PMID 42893452 · Screening colonoscopy utilization among adults living with spina bifida. · 8/10 · Early Detection
PMID 42893380 · The "living well with lupus" lifestyle intervention: Effects on gut microbiota in patients with systemic lupus erythematosus and high cardiovascular risk. · 8/10 · Public Health
PMID 42893275 · Impact of healthcare setting on survival in adults with acute lymphoblastic leukemia in Latin America: insights from a large multinational cohort. · 8/10 · Diagnostics
PMID 42893216 · Effectiveness of Yoga-based guided meditation In Improving the quality of sleep in patients with coronary artery disease: The Yoga Nidra Trial. · 8/10 · Other
PMID 42893203 · Real-world outcomes of mosunetuzumab use in relapsed/refractory indolent lymphomas: a CUBIC consortium analysis. · 8/10 · Diagnostics
PMID 42893198 · Pitavastatin counteracts venetoclax resistance mechanisms including TP53 mutation in acute myeloid leukemia. · 8/10 · Diagnostics
PMID 42893061 · Whole heart atherosclerosis volume and risk for major adverse cardiovascular events across the clinical likelihood for obstructive CAD; the CONFIRM2 study. · 8/10 · Other
PMID 42893056 · Rethinking the Platinum Standard in SCLC: A Meta-Analysis of Limited- and Extensive-Stage Disease in the Immunotherapy Era. · 8/10 · Treatment Innovation
PMID 42893054 · B-Lymphoblastic Leukemia Presenting as Bilateral Ovarian Masses in a 20-Year-Old Woman. · 8/10 · Diagnostics
PMID 42893041 · Heterogeneity in proteomic risk factors for coronary heart disease by sex and menopause status. · 8/10 · Other
PMID 42893008 · Delayed elective nodal irradiation in head-and-neck cancer radiotherapy reduces acute lymphocyte damage, lymphopenia, and modulates immune signatures. · 8/10 · Treatment Innovation
PMID 42892915 · Evaluating the safety of glucagon-like peptide-1 agonist use in non-diabetic overweight patients undergoing shoulder arthroplasty. · 8/10 · Public Health
PMID 42892554 · Outcomes of Allogeneic Stem Cell Transplantation in a North American Adult T Cell Leukemia/Lymphoma Cohort. · 8/10 · Treatment Innovation
PMID 42892446 · The cardiometabolic ageing-cardiovascular disease axis: A 32-year European study. · 8/10 · Public Health
PMID 42892418 · Genetic and clinical evidence supports HLA-DR(+) CD8(+) T cells as a favorable immune biomarker in acute myeloid leukemia. · 8/10 · Diagnostics
PMID 42892403 · A hierarchical residual Swin transformer with dual-level locality compensation for accelerated MRI reconstruction. · 8/10 · Diagnostics
PMID 42893888 · PRAME Immunohistochemistry and Molecular Profiling in Undifferentiated Cutaneous Pleomorphic Neoplasms: A Case Series of 8 Tumors. · 7/10 · Early Detection
PMID 42893791 · The PENIMA project: artificial intelligence decision-support tool for penile lesions - protocol paper and invitation to participate. · 7/10 · Early Detection
PMID 42893704 · Potential clinical significance of soluble and extracellular vesicle-bound HER2 in breast cancer. · 6/10 · Early Detection
PMID 42893449 · Harnessing the ion transportome to treat cancer. · 6/10 · Early Detection
PMID 42891659 · Diverse patterns of transcriptional regulation and epigenetic reprogramming within PMDs contribute to ESCC progression by regulating EMT and immunosuppression. · 5/10 · Early Detection
PMID 42893278 · Synchronous laryngeal squamous cell carcinoma and papillary urothelial carcinoma of the bladder: a case report and literature review. · 4/10 · Early Detection
PMID 42893112 · Delayed radiographic diagnosis of distal femoral metastases in breast cancer: A case report from Cocody University Teaching Hospital (Côte d'ivoire). · 4/10 · Early Detection

🟢⚪ STANDARD (5-7) — Top by Topic

PMID 42893900 · Subtype- and functional class-dependent prognostic impact of CSF3R mutations in acute myeloid leukaemia: A cohort study of 2500 patients. · 7/10 · Diagnostics
PMID 42893773 · Development of a Natural Language Processing Algorithm to Aid Creation of a Surgical Spine Database. · 7/10 · Diagnostics
PMID 42893227 · Pro-inflammatory cytokines moderated by visceral adiposity from a pragmatic randomized crossover trial of portable HEPA air purifiers. · 7/10 · Other
PMID 42893187 · Epicardial adipose tissue radiomics complement calcium scoring in black adults with type 2 diabetes mellitus. · 7/10 · Diagnostics
PMID 42893186 · Heart failure and atrial fibrillation prediction from non-gated chest CT scans using AI-based cardiac chamber volumetry: an AI-CVD study within the multi-ethnic study of atherosclerosis (MESA). · 7/10 · Other
PMID 42893050 · Brief Report: Reassessment of bTMB as a Predictive Biomarker in NSCLC Immunotherapy-A Reanalysis of OAK and POPLAR. · 7/10 · Treatment Innovation
PMID 42893035 · Inverse Association of the Life's Crucial 9 Score With MAFLD: An Exploratory Mediation Analysis of the C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index. · 7/10 · Public Health
PMID 42892957 · HeatRisk and air quality risk recommendations: A narrative review and action algorithm for the care of people at risk for and living with cardiovascular disease. · 7/10 · Public Health
PMID 42892808 · A prognostic model based on seven cell adhesion molecule-related genes to predict the prognosis of colorectal cancer. · 7/10 · Treatment Innovation
PMID 42892693 · Moral distress and moral injury among nurses in German acute inpatient care - a cross-sectional study. · 7/10 · Diagnostics
PMID 42892556 · Exercise, Dietary, and Combined Exercise-Dietary Interventions for Metabolic Syndrome: A Bayesian Network and Component Network Meta-Analysis of Randomized Controlled Trials. · 7/10 · Public Health
PMID 42892533 · Dermoscopy of intraepidermal keratinocytic neoplasms in solid organ transplant recipients: a single-center prospective real-world study supported by machine learning. · 7/10 · Diagnostics
PMID 42892471 · GLP-1 receptor agonist therapy and incident atrial fibrillation in non-diabetic adults with obesity and chronic kidney disease: a propensity matched cohort study. · 7/10 · Public Health
PMID 42892392 · ThaCoder: an explainable deep learning framework for thalassemia screening using routine complete blood count: a multi-center validation study. · 7/10 · Diagnostics
PMID 42892330 · Incidence of thrombosis and bleeding in patients with JAK2- positive myeloproliferative neoplasms receiving low-dose aspirin: a systematic review and meta-analysis. · 7/10 · Diagnostics
PMID 42893949 · Innovation and practices on case-based genetics teaching focusing on hereditary spastic paraplegia. · 6/10 · Genomics/Precision Medicine
PMID 42893921 · [Advances in the diagnosis and treatment of capillary malformation-arteriovenous malformation syndrome]. · 6/10 · Genomics/Precision Medicine
PMID 42893818 · Neuro-Immune Interactions in the Tumour Microenvironment: Implications for Cancer Progression and Treatment. · 6/10 · Treatment Innovation
PMID 42893768 · Dose Optimization of Immune Checkpoint Inhibitors: A Policy opportunity to reduce costs and improve access to immunotherapy in the United States. · 6/10 · Treatment Innovation
PMID 42893430 · Skeletal muscle transcriptomic profile of older adults with high-impact musculoskeletal pain in the study of muscle, mobility and aging (SOMMA). · 6/10 · Public Health
PMID 42893427 · Self-Rated Health Trajectories Among Adults Aged 51-64 Years at Baseline: A 10-Year Group-Based Trajectory Analysis Informed by Roy's Adaptation Model. · 6/10 · Public Health
PMID 42893247 · COPD Burden Across 48 Asian Locations, 2009-2023: Demographic Drivers and Socioeconomic Inequality. · 6/10 · Public Health
PMID 42893140 · Peptide-Mediated Precise Intracellular Delivery of Bioactive Substances. · 6/10 · Genomics/Precision Medicine
PMID 42892449 · Non-Coding RNAs in Cancer Treatment Resistance: Mechanistic Insights with a Focus on Circular RNAs. · 6/10 · Genomics/Precision Medicine
PMID 42891872 · Histotype and molecular subtype integration in epithelial ovarian cancer: implications for targeted treatment. · 6/10 · Genomics/Precision Medicine
PMID 42891769 · Ferroptosis in cancer: molecular mechanisms, tumour microenvironment, therapeutic resistance, and clinical translation. · 6/10 · Genomics/Precision Medicine
PMID 42891722 · Emerging roles of OSM and EDA2R-NIK signalling in cancer-associated muscle wasting. · 6/10 · Public Health
PMID 42893422 · Hesperidin Attenuates Vincristine-Induced Nephrotoxicity via Nrf2/HO-1 and PI3K/Akt/mTOR Signaling. · 5/10 · Diagnostics

💡 UNSOLICITED FINDS

PMID 42893216 · Effectiveness of Yoga-based guided meditation In Improving the quality of sleep in patients with coronary artery disease: The Yoga Nidra Trial.
PMID 42893061 · Whole heart atherosclerosis volume and risk for major adverse cardiovascular events across the clinical likelihood for obstructive CAD; the CONFIRM2 study.
PMID 42893041 · Heterogeneity in proteomic risk factors for coronary heart disease by sex and menopause status.
PMID 42893227 · Pro-inflammatory cytokines moderated by visceral adiposity from a pragmatic randomized crossover trial of portable HEPA air purifiers.
PMID 42893186 · Heart failure and atrial fibrillation prediction from non-gated chest CT scans using AI-based cardiac chamber volumetry: an AI-CVD study within the multi-ethnic study of atherosclerosis (MESA).

📊 TODAY'S BREAKDOWN

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): reviewed 15, kept 11, highest 8/10
CBC-based diagnostics and machine learning in hematology: reviewed 1, kept 1, highest 7/10
Early cancer detection (liquid biopsy, ctDNA, cfDNA): reviewed 15, kept 13, highest 9/10
AI/ML in clinical diagnostics and imaging: reviewed 15, kept 6, highest 8/10
Precision oncology and genomic medicine: reviewed 7, kept 4, highest 6/10
Novel therapeutics: immunotherapy, CAR-T, targeted therapy: reviewed 15, kept 10, highest 9/10
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: reviewed 15, kept 9, highest 8/10
Aging, longevity, and population health: reviewed 6, kept 4, highest 6/10
Rare diseases with high unmet need: reviewed 4, kept 4, highest 8/10
By source type: peer_reviewed 64 | preprint 0

🔧 RUN NOTES

All selected candidates were reconciled independently against ESummary and EFetch; missing IDs: 0.
Search sets above their caps are explicitly marked truncated in Output A.
Scoring used PubMed metadata and abstracts conservatively; no external alert was sent.