Daily digest · Wed · 14 Oct 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic malignancies

PMID:42868322 · VERIFY: A Phase III Trial of Rusfertide Versus Placebo in Phlebotomy-Dependent Patients With Polycythemia Vera Receiving Standard-of-Care Therapy. · 9/10 · Phase 3 clinical trial; directly matches Hematologic malignancies. Conservative abstract-level score 9/10. PMID:42868651 · Comparison of diagnostic yield of EBUS-guided transbronchial mediastinal cryobiopsy (EBUS-MCB) versus EBUS-guided transbronchial needle aspiration (EBUS-TBNA): A systematic review and meta-analysis. · 9/10 · Systematic review and meta-analysis; directly matches Hematologic malignancies. Conservative abstract-level score 9/10. PMID:42866645 · Comparative Outcomes of Single- and Split-Fraction Low-Dose Radiation in Mycosis Fungoides. · 8/10 · Retrospective observational study; directly matches Hematologic malignancies. Conservative abstract-level score 8/10.

CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).

Early cancer detection

PMID:42866570 · A Holistic Framework for Cervical Cancer Screening and Risk Stratification: Integrating Etiology, Morphology, Epigenetics, and Microecology. · 9/10 · Diagnostic validation study; directly matches Early cancer detection. Conservative abstract-level score 9/10. PMID:42867374 · Supplemental Breast Cancer Screening with Contrast-enhanced Mammography or Abbreviated MRI for Extremely Dense Breasts: The DENSE-2 Trial. · 9/10 · Randomized controlled trial; directly matches Early cancer detection. Conservative abstract-level score 9/10. PMID:42867728 · Optimizing AI-assisted decision-making in mammography screening: focusing on uncertainties. · 9/10 · Diagnostic validation study; directly matches Early cancer detection. Conservative abstract-level score 9/10. PMID:42868712 · Soluble N-terminal EphA2 fragment as a diagnostic biomarker and functional mediator of tumor progression in triple-negative breast cancer. · 8/10 · Diagnostic validation study; directly matches Early cancer detection. Conservative abstract-level score 8/10. PMID:42869026 · Early detection of gastric cancer using DNA features in red blood cells, with multicenter validation. · 8/10 · Diagnostic validation study; directly matches Early cancer detection, Precision oncology and genomic medicine. Conservative abstract-level score 8/10.

AI/ML in clinical diagnostics and imaging

PMID:42866727 · Histopathology-correlated evaluation of magnetic resonance spectroscopy for high-grade glioma prediction: A small-scale neuro-oncology study with exploratory machine learning. · 8/10 · Diagnostic validation study; directly matches AI/ML in clinical diagnostics and imaging. Conservative abstract-level score 8/10. PMID:42869163 · Association between iron metabolism biomarkers and all-cause mortality in critically ill patients with sepsis: a retrospective cohort study. · 8/10 · Retrospective observational study; directly matches AI/ML in clinical diagnostics and imaging. Conservative abstract-level score 8/10. PMID:42869550 · Reporting completeness of clinical trials evaluating large language model interventions in medicine: systematic review. · 8/10 · Systematic review and meta-analysis; directly matches AI/ML in clinical diagnostics and imaging. Conservative abstract-level score 8/10.

Precision oncology and genomic medicine

PMID:42866938 · TOMM5 is associated with oral cancer progression: a multi-omics analysis from single-cell atlas to in vitro validation. · 8/10 · Diagnostic validation study; directly matches Precision oncology and genomic medicine. Conservative abstract-level score 8/10. PMID:42869026 · Early detection of gastric cancer using DNA features in red blood cells, with multicenter validation. · 8/10 · Diagnostic validation study; directly matches Early cancer detection, Precision oncology and genomic medicine. Conservative abstract-level score 8/10. PMID:42869051 · Genomic ascertainment of systemic autoinflammatory diseases: a retrospective cohort study in two population-based biobanks. · 8/10 · Retrospective observational study; directly matches Precision oncology and genomic medicine. Conservative abstract-level score 8/10. PMID:42869130 · Inhibition of the MEK-ERK signaling pathway reverses acquired osimertinib resistance in NSCLC attributed to AXL overexpression. · 8/10 · Diagnostic validation study; directly matches Precision oncology and genomic medicine. Conservative abstract-level score 8/10.

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

PMID:42867382 · Claudin 18.2: From a Tight Junction Protein to a Breakthrough Target in Solid Tumor Immunotherapy. · 9/10 · Phase 3 clinical trial; directly matches Novel therapeutics: immunotherapy, CAR-T, targeted therapy. Conservative abstract-level score 9/10. PMID:42867445 · Combination therapies for the treatment of locally advanced and advanced cervical cancer. · 9/10 · Phase 3 clinical trial; directly matches Novel therapeutics: immunotherapy, CAR-T, targeted therapy. Conservative abstract-level score 9/10.

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

Aging, longevity, and population health

PMID:42867105 · Efficacy and Safety of Enlicitide in Hypercholesterolemia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. · 10/10 · Systematic review and meta-analysis; directly matches Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health. Conservative abstract-level score 10/10. PMID:42867868 · Risk Visualization With Petal-X and Continuous Glucose Monitoring to Support Person-Centered Care and Lifestyle Change in Cardiovascular Prevention: Qualitative Descriptive Study. · 9/10 · Randomized controlled trial; directly matches Aging, longevity, and population health. Conservative abstract-level score 9/10. PMID:42869428 · Feasibility of Online and On-Site Physical Activity Delivery Among Older Adults: Mixed Methods Pilot Randomized Controlled Trial. · 9/10 · Randomized controlled trial; directly matches Aging, longevity, and population health. Conservative abstract-level score 9/10. PMID:42867732 · Monocytic resilience during chemoradiotherapy is independently associated with survival in IDH-Wildtype glioblastoma. · 8/10 · Diagnostic validation study; directly matches Aging, longevity, and population health. Conservative abstract-level score 8/10.

Rare diseases with high unmet need

PMID:42867681 · Primary spinal bone sarcomas in Japan: a nationwide comparative analysis of demographic and pathologic features, treatment patterns, and survival. · 8/10 · Retrospective observational study; directly matches Rare diseases with high unmet need. Conservative abstract-level score 8/10. PMID:42869145 · Protein inhibitor of retinal membrane guanylyl cyclase rescues photoreceptors from degeneration induced by mutated guanylyl cyclase activating protein. · 8/10 · Prospective observational study; directly matches Rare diseases with high unmet need. Conservative abstract-level score 8/10.

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies

PMID:42869387 · Population Pharmacokinetic Estimation of Melphalan Exposure Predicts Disease Control and Toxicity after Autologous Hematopoietic Cell Transplantation for Multiple Myeloma. · 7/10 · Treatment Innovation PMID:42869643 · Elevated Risks for Depression and Anxiety Following Diagnosis of Multiple Myeloma. · 7/10 · Treatment Innovation PMID:42867841 · Real-World Survival Outcomes of Venetoclax Combination Therapies in Acute Myeloid Leukemia: Impact of Minimal Residual Disease Status and Antifungal Prophylaxis. · 6/10 · Treatment Innovation PMID:42868529 · Cost-Effectiveness of AI-Powered Decentralized Production for Advanced Therapies in the Hospital-Generated Chimeric Antigen Receptor T-Cell Therapy for Multiple Myeloma From a German Hospital Perspective: Early Health Technology Assessment Study. · 6/10 · Treatment Innovation PMID:42869018 · Rapid CAR-T manufacturing with low-intensity priming enhances CAR-T cell fitness and limits inflammatory programming in a phase 1 study. · 6/10 · Treatment Innovation

CBC-based diagnostics and machine learning in hematology

No retained standard-priority finds today.

Early cancer detection

PMID:42867147 · AI in Neuro-Oncology: An Overarching Review. · 7/10 · Early Detection PMID:42865696 · Nanoprobe-Enabled Precision Imaging and Panoramic Boundary Delineation in Retinoblastoma. · 6/10 · Early Detection PMID:42868113 · Psychological distress among women with abnormal cervical cancer screening results in Poland: Validation of the Polish version of the Cervical Dysplasia Distress Questionnaire (CDDQ-PL). · 6/10 · Early Detection PMID:42868284 · The use of TF-Ag-α to selectively capture tumor-derived extracellular vesicles and enhance the predictive performance of extracellular vesicle PD-L1 for response to immune checkpoint inhibitors. · 6/10 · Early Detection PMID:42869040 · [Molecular-Based Diagnostics and Therapy of Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)]. · 6/10 · Early Detection

AI/ML in clinical diagnostics and imaging

PMID:42868968 · Enhanced Early Risk Stratification in Cardiogenic Shock Using Machine Learning: A Hierarchical Clustering Analysis. · 7/10 · Diagnostics PMID:42869378 · Comparing Diagnostic Ability of Two Off-the-Shelf Large Language Models with That of Endodontists for Teeth Requiring Initial Root Canal Treatment: A Multicenter Retrospective Investigation. · 7/10 · Treatment Innovation PMID:42866117 · Activatable MRI nanoprobes for tumor and immune microenvironment imaging: biological mechanisms and translational implications. · 5/10 · Genomics/Precision Medicine PMID:42867037 · Hypertensive disorders of pregnancy: epidemiology, pathophysiology, therapeutic strategies, and maternal-offspring outcomes. · 5/10 · Genomics/Precision Medicine PMID:42869522 · Diagnostic Decision Support and Automation in Vestibular Diagnosis. · 5/10 · Diagnostics

Precision oncology and genomic medicine

PMID:42865985 · Single-cell and intercellular communication analyses reveal DLL3 as a key regulator in the glioma tumor microenvironment. · 6/10 · Genomics/Precision Medicine PMID:42868714 · Patient-derived gastric cancer organoids for functional precision oncology: disease-specific bottlenecks and clinical readiness. · 6/10 · Genomics/Precision Medicine PMID:42869040 · [Molecular-Based Diagnostics and Therapy of Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)]. · 6/10 · Early Detection PMID:42869087 · Testing the Avrami-Dobrzyński model of cancer transformation using mutation-count clinical data across multiple tumour types. · 6/10 · Genomics/Precision Medicine PMID:42866117 · Activatable MRI nanoprobes for tumor and immune microenvironment imaging: biological mechanisms and translational implications. · 5/10 · Genomics/Precision Medicine

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

PMID:42868630 · A second chance? Outcomes of immunotherapy retreatment after prior checkpoint inhibitor exposure in endometrial and cervical cancer. · 7/10 · Treatment Innovation PMID:42866117 · Activatable MRI nanoprobes for tumor and immune microenvironment imaging: biological mechanisms and translational implications. · 5/10 · Genomics/Precision Medicine PMID:42866595 · A zinc organic metal skeleton vaccine for lung cancer treatment can stimulate strong innate and adaptive anti-tumor immunity. · 5/10 · Genomics/Precision Medicine PMID:42866624 · Targeting mutant NPM1-expressing AML with T cell receptor-like antibodies. · 5/10 · Genomics/Precision Medicine PMID:42867541 · [Multimodal treatment of locally advanced and oligometastatic esophageal cancer]. · 5/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

PMID:42866041 · Effect of intraoperative high positive end-expiratory pressure with recruitment manoeuvres versus low positive end-expiratory pressure on postoperative lung function in obese adults: a substudy of the protective ventilation in obese patients randomised controlled trial. · 7/10 · Other PMID:42866653 · Respiratory failure nurse consultant model may decrease hospital days for acute respiratory failure: A single-centre descriptive implementation study. · 7/10 · Treatment Innovation PMID:42866035 · Plasma untargeted metabolomics in coronary artery disease - Correlation with degree of obstruction. · 5/10 · Other PMID:42867037 · Hypertensive disorders of pregnancy: epidemiology, pathophysiology, therapeutic strategies, and maternal-offspring outcomes. · 5/10 · Genomics/Precision Medicine PMID:42867412 · International Society of Sports Nutrition position stand: diets for body weight reduction. · 5/10 · Genomics/Precision Medicine

Aging, longevity, and population health

PMID:42867920 · Simplified bacterial identification and antimicrobial resistance detection in bacteraemia by on-chip multiplexed LAMP from blood cultures. · 7/10 · Diagnostics PMID:42867200 · Development of mRNA vaccines against herpes zoster. · 6/10 · Public Health PMID:42869779 · Clinical, economic, and health-related quality of life impact of intrapartum group B Streptococcus (GBS) tests for prevention of neonatal GBS infection: a systematic literature review. · 6/10 · Treatment Innovation PMID:42867037 · Hypertensive disorders of pregnancy: epidemiology, pathophysiology, therapeutic strategies, and maternal-offspring outcomes. · 5/10 · Genomics/Precision Medicine PMID:42867717 · Computational Modeling of Neurotransmitter Cycling Predicts Human Brain Glutamate and GABA Dynamics in Response to Acute Administration of Exogenous Ketones. · 5/10 · Treatment Innovation

Rare diseases with high unmet need

PMID:42866647 · Microenvironment shapes Staphylococcus aureus phenotypes in children with cystic fibrosis over time. · 7/10 · Treatment Innovation PMID:42868225 · Advances in Stem Cell Therapy for Hearing Loss. · 7/10 · Treatment Innovation PMID:42867329 · Anti-mycobacterial activity of phage-encoded lysterases. · 6/10 · Treatment Innovation PMID:42867460 · What Does It Mean to Be Cured?: Perspectives from Individuals Living with Sickle Cell Disease. · 6/10 · Treatment Innovation PMID:42867740 · Oculopharyngeal Muscular Dystrophy: From Molecular Pathogenesis to Gene Therapy. · 6/10 · Treatment Innovation

💡 UNSOLICITED FINDS

PMID:42869063 · Hearing loss, hearing-aid use, and mortality risk: individual participant data meta-analysis of population-based studies from Australia, Iceland, and the USA and a replication study from Norway. · 8/10 · Public Health PMID:42868199 · Estradiol-associated extracellular signaling in the human breast in vivo identifies mast cells as tumor-supportive stromal mediators. · 6/10 · Treatment Innovation PMID:42866596 · Leveraging artificial intelligence to strengthen cancer care in Belgium: a policy brief from the Belgian Europe's Beating Cancer Plan Mirror Group. · 5/10 · Treatment Innovation PMID:42866644 · Supportive care needs of patients with proliferative diabetic retinopathy: A qualitative study. · 5/10 · Treatment Innovation

📊 TODAY'S BREAKDOWN

By research category: Diagnostics 8, Early Detection 10, Genomics/Precision Medicine 12, Other 2, Public Health 4, Treatment Innovation 26
By evidence maturity: Exploratory 28, Validated 34
By watchlist topic:
- Hematologic malignancies: 15 reviewed / 9 kept / highest 9
- CBC-based diagnostics and machine learning in hematology: 0 reviewed / 0 kept / highest 0
- Early cancer detection: 15 reviewed / 10 kept / highest 9
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 8 kept / highest 8
- Precision oncology and genomic medicine: 15 reviewed / 10 kept / highest 8
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 7 kept / highest 9
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 7 kept / highest 10
- Aging, longevity, and population health: 15 reviewed / 9 kept / highest 10
- Rare diseases with high unmet need: 15 reviewed / 7 kept / highest 8
By source type: peer_reviewed 62 | preprint 0
Topics with zero HIGH articles this run: CBC-based diagnostics and machine learning in hematology

🔧 RUN NOTES

Complete capped rerun; same-date prior emissions were not excluded from the daily JSON.
T2 primary and configured fallback both returned zero records.
PubMed results exceeding caps were truncated only after publication-date ordering; all selected PMIDs were reconciled.