Daily digest · Sat · 10 Oct 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

[42854088] · Lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome: a systematic review and network meta-analysis · 9/10 · High-level evidence synthesis; high triage score [42855136] · Diagnostic Performance of Common Biochemical Screening Tests for Mild Autonomous Cortisol Secretion in Adrenal Incidentalomas: A Systematic Review and Hierarchical SROC Meta-analysis · 8/10 · High-level evidence synthesis; high triage score [42854284] · Home versus centre exercise-based cardiac rehabilitation after coronary artery bypass grafting: a systematic review and meta-analysis · 8/10 · High-level evidence synthesis; high triage score [42850789] · Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis · 8/10 · High-level evidence synthesis; high triage score

Rare diseases with high unmet need

[42852926] · Matching-adjusted indirect treatment comparisons in chronic inflammatory demyelinating polyneuropathy: interpreting current evidence and enhancing future studies · 8/10 · High-level evidence synthesis; high triage score

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma) [42855204] · Imaging Review of Small Bowel Pathologies (Benign and Malignant) · 6/10 · Treatment Innovation [42854217] · Urolithiasis in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (ALL/LLy): A Single-Center Case Series of Clinical, Metabolic, and Imaging Features · 6/10 · Treatment Innovation [42854053] · SF3B1-mutated MDS coexisting with β-thalassemia trait: A case report and literature review focused on diagnostic distinction from acquired β-thalassemia · 6/10 · Treatment Innovation [42852632] · Resistance to covalent Bruton's tyrosine kinase inhibitors in diffuse large B‑cell lymphoma: Molecular mechanisms and therapeutic implications (Review) · 6/10 · Treatment Innovation

Early cancer detection (liquid biopsy, ctDNA, cfDNA) [42854587] · Nivolumab in patients with advanced solid tumors with ctDNA-defined high blood tumor mutational burden: a phase II trial · 7/10 · Early Detection [42851191] · [Expert consensus on next-generation sequencing of common tumor driver genes using body fluid-derived cfDNA (2026 version)] · 7/10 · Early Detection [42855393] · Converging Focused Ultrasound and Liquid Biopsy for Glioma Management: Next Steps · 6/10 · Early Detection [42852307] · Beyond the Oropharynx: TTMV-HPV DNA Detection in a p16-Positive Hypopharyngeal Squamous Cell Carcinoma · 6/10 · Early Detection

AI/ML in clinical diagnostics and imaging [42854985] · International consensuses and guidelines on etiology, diagnosis, and treatment of retinal vein occlusion (RVO) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO), Asia-Pacific Vitreo-retina Society (APVRS) and Academia Retina Internationalis (ARI) · 7/10 · Diagnostics [42854913] · Knowledge-guided Multimodal Learning for Interpretable Prediction of Pathological Complete Response and Survival in Breast Cancer · 7/10 · Diagnostics [42854833] · An update on miRNAs as non-invasive diagnostic markers for endometriosis: Why have we not reached consensus? · 7/10 · Diagnostics [42854258] · Integrity of artificial intelligence and machine learning evidence in spine surgery: a critical appraisal of systematic reviews · 7/10 · Diagnostics [42855393] · Converging Focused Ultrasound and Liquid Biopsy for Glioma Management: Next Steps · 6/10 · Early Detection

Precision oncology and genomic medicine [42854216] · Individualized Therapy Optimization for Type 2 Diabetes: Retrospective Study of Model Development, Internal Validation, and Physician Evaluation · 7/10 · Genomics/Precision Medicine [42855393] · Converging Focused Ultrasound and Liquid Biopsy for Glioma Management: Next Steps · 6/10 · Early Detection [42855278] · Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome · 6/10 · Genomics/Precision Medicine [42855111] · Beyond blood pressure: AI-assisted multi-omics biomarker stratification for stroke risk in hypertension: clinical chemistry, analytical validation, and translational perspectives · 6/10 · Genomics/Precision Medicine [42855042] · Genome-wide association studies of osteoarthritis: from genetic discovery to precision medicine · 6/10 · Genomics/Precision Medicine

Novel therapeutics: immunotherapy, CAR-T, targeted therapy [42854996] · Circular RNAs in Breast Cancer Immunometabolism: Mechanisms of Immune Regulation and Metabolic Reprogramming · 6/10 · Genomics/Precision Medicine [42854988] · Efficacy of Dupilumab for Patients with Chronic Rhinosinusitis without Nasal Polyps: a Randomized Double-Blind Placebo Controlled Phase II Study · 6/10 · Treatment Innovation [42853659] · IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma · 6/10 · Treatment Innovation [42852637] · Comprehensive landscape and future perspectives of PIWI‑interacting RNAs in cancer (Review) · 6/10 · Early Detection [42852635] · cGAS‑STING pathway in digestive tract cancer: From molecular mechanisms to therapeutic applications (Review) · 6/10 · Treatment Innovation

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk [42855378] · Status Of GLP-1 drugs and their application in treating substance use disorders: A systematic review · 7/10 · Prevention [42855133] · Weight Management in Obesity-Associated Sleep-Disordered Breathing: Mechanisms, Clinical Management, and Emerging Therapies · 7/10 · Prevention [42854854] · Prevalence of Diabetic Retinopathy and Cardiovascular Risk Factors Among Diverse Hispanic/Latino Adults: HCHS/SOL and SOL Ojos Results · 7/10 · Prevention [42854282] · Prognostic significance of isolated left bundle branch block in patients presenting with chest pain without prior cardiometabolic disease · 7/10 · Prevention [42853626] · Association between Chinese visceral adiposity index and prevalent hypertension among older adults in rural China: A cross-sectional study · 7/10 · Prevention

Aging, longevity, and population health [42853420] · Global and regional amyloid-β in explaining APOE-ε4 and sex associations with medial temporal tau: a neuropathology study · 7/10 · Public Health [42852608] · Intergenerational educational mobility and intrinsic capacity in later life: a harmonised analysis of individuals from five countries · 7/10 · Public Health [42854076] · Global trends in young and older adult esophageal cancer burden from 1990 to 2021: An observational analysis for the Global Burden of Disease study 2021 · 6/10 · Public Health [42854061] · Trends, decomposition, and projections of gout burden among middle-aged adults in China: GBD 2023 · 6/10 · Public Health [42854059] · Shared genetic architecture between constipation and aging-related phenotypes: Insights from large-scale genome-wide cross-trait analysis · 6/10 · Public Health

Rare diseases with high unmet need [42855377] · Making space for cures: Conditioning for autologous hematopoietic stem cell gene therapies · 7/10 · Drug Development [42854433] · A smart multi-activatable DNAzyme nanoamplifier for spatiotemporal imaging of multiple piRNAs and on-demand gene therapy · 7/10 · Drug Development [42852943] · Directing mutant huntingtin towards degradation: Strategies and therapeutic opportunities · 7/10 · Drug Development [42852333] · Stiff-Person Syndrome: A Comprehensive Review of a Rare Disease with Emphasis on Pathophysiology, Clinical Features, Diagnostic Challenges and Therapeutic Advances · 7/10 · Drug Development [42852022] · Rare Diseases as Engines of Biomedical Innovation: Lessons for Gene Therapy and Common Disease · 7/10 · Drug Development

💡 UNSOLICITED FINDS

[42853711] · Dose-dependent effects of sodium bicarbonate supplementation combined with sprint interval training on performance adaptations in basketball players: a randomized placebo-controlled trial · 7/10 · CONCLUSION: Four weeks of SIT improved performance in trained basketball players, with Sb supplementation providing additional dose-dependent benefits (0.45 > 0.3 g⋅kg-1). [42853299] · Making recovery conceivable: perspectives from healthcare professionals using psychologically and behaviourally informed approaches to chronic fatigue syndrome · 5/10 · CONCLUSIONS: Participating HCPs described explanatory frameworks, their application in practice, therapeutic relationships, and patients' embodied experiences of improvement as interacting to make recovery conceivable. [42852733] · Functional thiamine deficiency in patients with chronic kidney disease in Northeast Thailand · 5/10 · In the multivariable analysis adjusted for age, sex, SBP, eGFR, and alcohol intake, hypertension remained independently associated with functional thiamine deficiency (β = 2.202; 95% confidence interval (CI) for the corresponding odds ratio (OR): 2.311-35.383; p = 0.002). [42850864] · [THE MEDICAL DEMOGRAPHIC AND EPIDEMIOLOGICAL CHARACTERISTICS OF ONCOLOGICAL DISEASES IN THE OSH OBLAST] · 5/10 · Полученные данные свидетельствуют о высокой онкологической нагрузке в Ошской области и подчеркивают необходимость дальнейшего совершенствования организации онкологической помощи и программ раннего выявления заболеваний. [42850863] · [IMPLEMENTATION OF A DYNAMIC SURVEILLANCE PROGRAM FOR EARLY CANCER DETECTION IN HEALTHY INDIVIDUALS CARRYING PATHOGENIC VARIANTS] · 5/10 · Предложенная модель может рассматриваться как организационный прототип наблюдения пациентов из групп высокого наследственного онкологического риска.

📊 TODAY'S BREAKDOWN

By research category: Treatment Innovation 10; Prevention 6; Drug Development 6; Early Detection 5; Genomics/Precision Medicine 5; Other 5; Public Health 5; Diagnostics 4
By evidence maturity: Exploratory 29; Validated 14; Potentially Practice-Changing 3
By watchlist topic (reviewed / kept / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 / 4 / 6
- CBC-based diagnostics and machine learning in hematology: 0 / 0 / 0
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 9 / 4 / 7
- AI/ML in clinical diagnostics and imaging: 15 / 5 / 7
- Precision oncology and genomic medicine: 15 / 6 / 7
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 / 6 / 6
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 / 9 / 9
- Aging, longevity, and population health: 15 / 5 / 7
- Rare diseases with high unmet need: 15 / 6 / 8
- Sentinel scan: 10 / 5 / 7
By source type: peer_reviewed 46 | preprint 0
Topics with zero 8+ articles this run: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma) (best 6/10); CBC-based diagnostics and machine learning in hematology (best 0/10); Early cancer detection (liquid biopsy, ctDNA, cfDNA) (best 7/10); AI/ML in clinical diagnostics and imaging (best 7/10); Precision oncology and genomic medicine (best 7/10); Novel therapeutics: immunotherapy, CAR-T, targeted therapy (best 6/10); Aging, longevity, and population health (best 7/10)

🔧 RUN NOTES

The CRDT search covered 2026-10-09 through 2026-10-10; no expansion was needed because the run found at least five relevant records.
All 116 unique selected PMIDs were reconciled in ESummary and EFetch; no metadata records were missing.
CBC/ML hematology primary and fallback queries both returned zero records.
Detection and treatment flags were applied conservatively; title-only and unverified treatment-monitoring records received no evidence-dependent flag.
Articles are sorted by triage_score descending.