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‹ Sat · 10 Oct 2026
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Diagnostic Performance of Common Biochemical Screening Tests for Mild Autonomous Cortisol Secretion in Adrenal Incidentalomas: A Systematic Review and Hierarchical SROC Meta-analysis

Simple blood tests can help identify adrenal conditions linked to heart and metabolic risk, though results need clinical judgment to guide next steps.

OBJECTIVE: Mild autonomous cortisol secretion (MACS) is a biochemical phenotype in adrenal incidentalomas associated with cardiometabolic risk. Positive results require clinical context and confirmatory evaluation when appropriate.

What the study was

Study design
Systematic Review
Population
OBJECTIVE: Mild autonomous cortisol secretion (MACS) is a biochemical phenotype in adrenal incidenta
Sample size
1420
Category
Prevention
Maturity
Validated
Journal
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

Why it surfaced

High-level evidence synthesis; high triage score

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