📅 PUBMED DAILY TRIAGE — 2026-10-09 Window: 2026-10-08T00:00:00Z → 2026-10-09T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: 124 | Candidates evaluated: 129 High priority: 3 | Standard: 40 | Low/archive: 81 | Unsolicited finds: 5 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID:42849654 · GAMMA: A genetic-clinical prognostic model for risk stratification in patients with relapsed/refractory acute myeloid leukemia receiving allogeneic hematopoietic stem cell transplantation · 8/10 · A total of 297 R/R AML patients from 11 other HSCT centers in China were included in the external validation group PMID:42845042 · Molecular surveillance of aggressive large B-cell lymphoma using circulating tumor DNA duplexes · 8/10 · Overall, we demonstrate that ctDNA monitoring using an ultrasensitive technique provides a dynamic molecular tool to guide clinical decision-making during therapy and follow-up in patients with LBCL
CBC-based diagnostics and machine learning in hematology
CBC-based diagnostics and machine learning in hematology: No high-priority finds today (best candidate scored 0/10).
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
Early cancer detection (liquid biopsy, ctDNA, cfDNA): No high-priority finds today (best candidate scored 0/10).
AI/ML in clinical diagnostics and imaging
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate scored 7/10).
Precision oncology and genomic medicine
PMID:42848264 · Analytical and Clinical Validation of the Oncomine Dx Express Test, an In Vitro Diagnostic-Labeled Assay, for Genomic Profiling of FFPE Tumor Samples · 8/10 · Similarly, the ODxET assay showed high clinical concordance with the clinical trial assays for EGFR exon 20 insertions, with a PPA of 97.9%, a NPA of 100%, and an overall percent agreement (OPA) of 98.9%
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
Novel therapeutics: immunotherapy, CAR-T, targeted therapy: No high-priority finds today (best candidate scored 6/10).
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds today (best candidate scored 7/10).
Aging, longevity, and population health
Aging, longevity, and population health: No high-priority finds today (best candidate scored 6/10).
Rare diseases with high unmet need
Rare diseases with high unmet need: No high-priority finds today (best candidate scored 7/10).
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
PMID:42848781 · Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial · 6/10 · Other PMID:42848504 · Clathrin recruitment and assembly of phosphorylated B cell receptor is impaired in human diffuse large B cell lymphoma · 6/10 · Other PMID:42849448 · Reviving low-affinity glycan-targeting CAR with combinatorial design · 5/10 · Treatment Innovation PMID:42849369 · Are quality of life data reported in clinical trials evaluating CAR T cells in hematologic malignancies? · 5/10 · Treatment Innovation
CBC-based diagnostics and machine learning in hematology
No retained standard-priority articles.
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
No retained standard-priority articles.
AI/ML in clinical diagnostics and imaging
PMID:42849491 · Conversational diagnostic artificial intelligence in ambulatory primary care: a prospective feasibility study · 7/10 · Diagnostics PMID:42849899 · Ensemble of Domain-Specific Natural Language Processing and Large Language Models for Detecting Suicidal Ideation and Mental Health Conditions in Social Media Text: Development and Evaluation Study · 6/10 · Diagnostics PMID:42849649 · Machine learning-aided serum N-glycomic signatures reveal potential biomarkers for acute ischemic stroke and minocycline treatment response · 6/10 · Treatment Innovation PMID:42849513 · Surgical Artificial Intelligence Innovation Trends and Regulatory Insights: A Systematic Analysis of Food and Drug Administration-Approved Devices · 6/10 · Diagnostics PMID:42849510 · Multi-scale temporal feature fusion and lead-graph attention for multi-label classification of 12-lead ECGs · 6/10 · Diagnostics
Precision oncology and genomic medicine
PMID:42849445 · Prognostic value of cfDNA methylation in locally advanced esophageal squamous cell cancer treated with neoadjuvant immunochemoradiotherapy · 7/10 · Genomics/Precision Medicine PMID:42848825 · Genotype-informed docosahexaenoic acid dosing based on the FADS Indel to reduce preterm and prolonged gestation: A secondary analysis of the ADORE randomized trial · 7/10 · Genomics/Precision Medicine PMID:42848441 · FIND: a phase-II study to evaluate the efficacy and safety of erdafitinib in FGFR-altered NSCLC · 7/10 · Genomics/Precision Medicine PMID:42844772 · Utility of Early Post-Treatment Circulating Tumor Tissue Modified Viral HPV DNA Testing in HPV-Associated Oropharyngeal Cancer · 7/10 · Genomics/Precision Medicine PMID:42849447 · Human genetic evidence challenges NCOA1 as a monogenic obesity gene · 6/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
PMID:42850038 · 68Ga-Labeled Dimeric Cyclic Peptide for Nectin-4-Targeted PET Imaging: From Preclinical Evaluation to First-in-Human Imaging in Breast Cancer · 6/10 · Treatment Innovation PMID:42849672 · Multivalent protein nanocages improve the safety profile of cluster of differentiation 47 checkpoint blockade · 5/10 · Treatment Innovation PMID:42849448 · Reviving low-affinity glycan-targeting CAR with combinatorial design · 5/10 · Treatment Innovation PMID:42849369 · Are quality of life data reported in clinical trials evaluating CAR T cells in hematologic malignancies? · 5/10 · Treatment Innovation PMID:42845003 · Dynamic changes of claudin 18.2 expression after systemic therapy in gastric and esophagogastric junction cancer · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
PMID:42849838 · Plasma omega-3 and omega-6 polyunsaturated fatty acid levels and risk for total mortality: The Mexico City Prospective Study · 7/10 · Other PMID:42850058 · GLP-1 Receptor Agonist Therapy for Glucocorticoid-Induced Dysglycaemia: A Systematic Review · 6/10 · Other PMID:42849688 · Tirzepatide alleviates hepatic steatosis and inflammation in MASLD partly through suppression of macrophage Dectin-1/Syk/NF-κB signaling · 5/10 · Other PMID:42848257 · Exercise, Nutrition and GLP-1 Medicines to Improve Body Weight and Muscle Function in Heart Failure with Preserved Ejection Fraction · 5/10 · Other PMID:42848089 · Mechanometabolic endothelial senescence as a translational framework for cardiometabolic vascular disease and vascular ageing · 5/10 · Public Health
Aging, longevity, and population health
PMID:42849064 · Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial · 6/10 · Public Health PMID:42849039 · Trends in Age and Socioeconomic Inequalities in Telemedicine Adoption in Japan, 2020-2024: Longitudinal Panel Study · 6/10 · Public Health PMID:42848789 · Assessing age-friendly urban environments in Indonesia: Validation of the Indonesian age-friendly cities and communities questionnaire (AFCCQ) and differences across urban city categories · 6/10 · Public Health PMID:42844958 · Polyphenol-Rich Foods as a Healthy and Sustainable Strategy: Mental Health and Metabolomic Profiling · 6/10 · Public Health PMID:42848653 · Weight loss-independent associations of body composition changes with device-derived metabolic age during Mediterranean diet follow-up · 5/10 · Public Health
Rare diseases with high unmet need
PMID:42847941 · Real-World Outcomes of First-Line Rituximab in Immune Thrombotic Thrombocytopenic Purpura · 7/10 · Genomics/Precision Medicine PMID:42847595 · Microperimetry Sensitivity Changes at the Functional Transition Zone and at the EZ Margins in X-Linked Retinitis Pigmentosa Treated With Gene Therapy · 6/10 · Genomics/Precision Medicine PMID:42844944 · KCNA2-Associated Hereditary Spastic Paraplegia: Clinical Characteristics and Rationale for Targeted Treatment · 6/10 · Genomics/Precision Medicine PMID:42849830 · Reframing liver test abnormalities after AAV gene therapy: a mechanistic diagnostic framework · 5/10 · Genomics/Precision Medicine PMID:42847178 · Harmonizing ALS research data across multimodal data sets using the OMOP Common Data Model · 5/10 · Genomics/Precision Medicine
💡 UNSOLICITED FINDS
PMID:42845017 · Sex Differences in Mortality After Myocardial Infarction: A German Nationwide Cohort Study · 7/10 · Because the adjustment included variables that may act as mediators on the causal pathway between sex and mortality, the adjusted estimates should be interpreted with caution PMID:42849061 · Optimizing pneumococcal prevention in South African older adults: Cost-effectiveness of PCV20 versus PPSV23 in the context of HIV-associated risk · 6/10 · Vaccinating all older adults universally may not be cost-effective at current prices, suggesting that targeted vaccination of older adults with HIV represents a more efficient strategy PMID:42846850 · Efficacy and safety of ketamine for post-traumatic stress disorder: A systematic review with narrative synthesis and consideration of military and veteran populations · 6/10 · Current evidence suggests that ketamine may be associated with short-term reductions in PTSD symptoms in some populations; however, findings remain preliminary due to small samples, heterogeneous designs, brief follow-up, and inconsistent safety reporting PMID:42845015 · Incidence and Survival Trends in Cancer of Unknown Primary (CUP): An Analysis From the North Rhine-Westphalia Cancer Registry, 2007-2023 · 6/10 · Of all types of CUP, squamous cell carcinoma was associated with the highest RS (42.8%), and adenocarcinoma and undifferentiated carcinoma with the lowest (14-15%) PMID:42848519 · Index-window C-reactive protein and carcinoembryonic antigen and five-year all-cause mortality in Hispanic/Latino and non-Hispanic White patients with colorectal cancer: a retrospective biomarker cohort study · 5/10 · Higher log(CEA + 0.1) (HR, 1.266; 95% CI, 1.174-1.366; P < 0.001) and log(CRP + 0.1) (HR, 1.134; 95% CI, 1.037-1.239; P = 0.006) were associated with mortality
📊 TODAY'S BREAKDOWN
- By research category: Diagnostics 6, Genomics/Precision Medicine 12, Other 12, Public Health 6, Treatment Innovation 7
- By evidence maturity: Exploratory 17, Validated 26
- By watchlist topic:
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed / 6 kept / highest 8
- CBC-based diagnostics and machine learning in hematology: 1 reviewed / 0 kept / highest 0
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 15 reviewed / 0 kept / highest 0
- AI/ML in clinical diagnostics and imaging: 15 reviewed / 6 kept / highest 7
- Precision oncology and genomic medicine: 15 reviewed / 7 kept / highest 8
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed / 6 kept / highest 6
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed / 5 kept / highest 7
- Aging, longevity, and population health: 15 reviewed / 6 kept / highest 6
- Rare diseases with high unmet need: 13 reviewed / 5 kept / highest 7
- Sentinel scan: 10 reviewed / 5 kept / highest 7
- By source type: peer_reviewed 43 | preprint 0
- Topics with zero 8+ articles this run: CBC-based diagnostics and machine learning in hematology, Early cancer detection (liquid biopsy, ctDNA, cfDNA), AI/ML in clinical diagnostics and imaging, Novel therapeutics: immunotherapy, CAR-T, targeted therapy, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health, Rare diseases with high unmet need
🔧 RUN NOTES
- All per-topic searches used the inclusive two-date CRDT window and the required newest-first sort; caps were 15 per watchlist topic and 10 for sentinel.
- ESummary and EFetch coverage reconciled all 124 unique selected PMIDs with no missing records.
- CBC/ML and early-cancer-detection candidates were conservatively reclassified where abstracts did not support the originating topic.
- This rerun regenerated the complete daily corpus and did not send duplicate Telegram alerts.