Reactive oxygen species define leukemia stem cell identity in pediatric acute myeloid leukemia.
Identifying which leukemia stem cells drive disease could help researchers design better therapies to stop cancer regrowth.
We found that RL cells exhibited increased quiescence, sustained serial colony-forming capacity and engraftment in mice when compared to the RH fraction. Finally, transcriptional program trajectory indicated that RL fraction contributed to generate the whole AML bulk, whereas gene mutations were maintained in RL and RH cells.
What the study was
- Study design
- Preclinical animal study
- Population
- Children and adolescents
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Cancer letters
Why it surfaced
Matched Hematologic malignancies; Preclinical animal study; mixed evidence; conservative score 7/10.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.