Reconstruction robustness of liver-referenced adaptive thresholding for 68Ga-PSMA-11 PET/CT volumetry: a comparative analysis of systematic bias and individual-patient variability
OBJECTIVE: PSMA tumor volume (PSMA-TV) is increasingly investigated as a quantitative biomarker for treatment assessment and prognostic stratification in metastatic castration-resistant prostate cancer (mCRPC). Relative SUVmax-based segmentation showed substantially greater susceptibility to reconstruction changes.
OBJECTIVE: PSMA tumor volume (PSMA-TV) is increasingly investigated as a quantitative biomarker for treatment assessment and prognostic stratification in metastatic castration-resistant prostate cancer (mCRPC). Relative SUVmax-based segmentation showed substantially greater susceptibility to reconstruction changes.
What the study was
- Study design
- Multicenter cohort study
- Population
- Patients
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Annals of nuclear medicine
Why it surfaced
Matched Precision oncology and genomic medicine; Multicenter cohort study; human study; score 8/10 (n=2 r=2 dq=2 pop=2)
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