📅 PUBMED DAILY TRIAGE — 2026-08-18 Window: 2026-08-17T00:00:00Z → 2026-08-18T23:59:59Z (CRDT) Topics scanned: 10 | Articles reviewed: 109 | Candidates selected: 109 High priority: 14 | Standard: 28 | Low/archive: 0 | Unsolicited finds: 3 Run status: PARTIAL_SUCCESS
🔴🟠 HIGH PRIORITY — Best Finds by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): No high-priority finds (best candidate 7/10 [42608256])
CBC-based diagnostics and machine learning in hematology: No candidates in CRDT window
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
- 42607848 · Novel immunotherapeutic strategies for colorectal cancer treatment: Advances, ch · 7/10 🔴 Early cancer detection or prevention
- 42606335 · Whole Genome HPV Liquid Biopsy for HPV-Associated Cancer Detection and Viral Phy · 7/10 🔴 Early cancer detection or prevention
- 42607937 · Integration of PNA-mediated PCR and CRISPR/Cas13a for highly sensitive detection · 6/10 🔴 Early cancer detection or prevention
- 42607918 · Circular RNAs as diagnostic biomarkers and therapeutic regulators of metabolic r · 5/10 🔴 Early cancer detection or prevention
AI/ML in clinical diagnostics and imaging: No high-priority finds (best candidate 6/10 [42608308])
Precision oncology and genomic medicine: No high-priority finds (best candidate 7/10 [42607848])
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- 42608132 · Dihydropyrimidine dehydrogenase modulates immune response to checkpoint inhibiti · 7/10 🟠 Novel or significantly improved treatment
- 42607553 · Chelerythrine and chelidonine synergistically target the adenosine pathway to im · 5/10 🟠 Novel or significantly improved treatment
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: No high-priority finds (best candidate 7/10 [42607995])
Aging, longevity, and population health: No high-priority finds (best candidate 6/10 [42606800])
Rare diseases with high unmet need
- 42605174 · Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series. · 7/10 🟠 Novel or significantly improved treatment
- 42606679 · Leveraging Informal Caregiving Skills to Reach Rural Contexts: Results from Cont · 7/10 🟠 Novel or significantly improved treatment
- 42608073 · Targeted complement inhibition with pozelimab in children with CD55 deficiency. · 7/10 🟠 Novel or significantly improved treatment
- 42608275 · On-target and off-target activities of CRISPR therapeutics across scales. · 5/10 🟠 Novel or significantly improved treatment
- 42605926 · Therapeutic Advances and Biomarkers in Multiple Sclerosis. · 5/10 🟠 Novel or significantly improved treatment
💡 Sentinel High-Priority Finds
- 42608373 · Effects of General Versus Regional Anaesthesia on Surgical Outcomes and Early Po · 8/10 ⚪ Promising but preliminary [UNSOLICITED]
- 42608319 · Glycated Albumin Guided Therapy in Newly Diagnosed Type 2 Diabetes A Randomized · 8/10 ⚪ Promising but preliminary [UNSOLICITED]
- 42608299 · [Preventive effect of Saccharomyces boulardii combined with Bifidobacterium quad · 8/10 🟢 Near-term implementable finding [UNSOLICITED]
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)
- 42608256 · Sequential TKI Treatment in Patients With Chronic Phase Chronic Myeloid Leukemia · 7/10 · Treatment Innovation
- 42608172 · Real-world outcomes of venetoclax plus hypomethylating agents in unfit acute mye · 7/10 · Treatment Innovation
- 42607815 · Gut microbiome crosstalk in acute myeloid leukemia: mechanisms, treatment-associ · 6/10 · Treatment Innovation
- 42608161 · Trends and socio-economic disparities in chronic lymphocytic leukaemia 2014-2022 · 6/10 · Treatment Innovation
- 42608144 · Glofitamab in combination with immunochemotherapy in patients with relapsed/refr · 6/10 · Treatment Innovation
AI/ML in clinical diagnostics and imaging
- 42607977 · Federated learning for MRI-based BrainAGE: A multicenter study on post-stroke fu · 6/10 · Diagnostics
- 42607540 · The role of artificial intelligence in predicting readmission risk in emergency · 6/10 · Diagnostics
- 42608308 · [Construction of a genotype-phenotype database and machine learning models for p · 6/10 · Diagnostics
- 42607398 · Deep learning electrocardiogram analysis for rapid rule-out of acute coronary sy · 6/10 · Diagnostics
- 42607088 · Artificial Intelligence and Machine Learning-based prediction of tuberculosis tr · 6/10 · Diagnostics
Precision oncology and genomic medicine
- 42607556 · Comprehensive review of natural products targeting lapatinib resistance-related · 5/10 · Genomics/Precision Medicine
- 42608184 · On the role of Y chromosome loss in malignancies: the driving mechanisms and pot · 5/10 · Genomics/Precision Medicine
- 42607933 · The senescence-immune axis as a target for combining immunotherapy and senothera · 5/10 · Treatment Innovation
- 42607632 · Association between inflammatory score and incident cancer risk among middle-age · 5/10 · Genomics/Precision Medicine
Novel therapeutics: immunotherapy, CAR-T, targeted therapy
- 42608361 · Oncological Outcomes of Intravesical Bacillus Calmette-Guérin Versus Early · 7/10 · Treatment Innovation
- 42607544 · Clinical characteristics and outcomes of patients with autoimmune encephalitis a · 6/10 · Treatment Innovation
- 42608364 · Development of a Nomogram Incorporating Multiparametric MRI and Clinical Indicat · 5/10 · Treatment Innovation
- 42608244 · The niche-metabolism axis: reprogramming tumor-associated macrophages for precis · 5/10 · Treatment Innovation
- 42607753 · Severe Checkpoint Inhibitor Pneumonitis and Lung Cancer Recurrence After Carbon- · 5/10 · Treatment Innovation
Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk
- 42607995 · Stroke risk in diabetic patients with concomitant cardiovascular disease the CAR · 7/10 · Prevention
- 42608180 · NT-proBNP in relation to clinical characteristics and cardiovascular outcomes in · 6/10 · Prevention
- 42608017 · Independent, Stratified, and Joint Associations of Sedentary Time and Physical A · 6/10 · Prevention
- 42608342 · Therapies for Cardiovascular-Kidney-Liver-Metabolic Syndrome: Reappraisal of Fib · 5/10 · Prevention
- 42608333 · Association of Lipid Ratios With Cardiovascular Outcomes in Type 2 Diabetes: A P · 5/10 · Prevention
Aging, longevity, and population health
- 42606800 · Disproportionate expansion of radical prostatectomy among older men in Japan in · 6/10 · Public Health
- 42606999 · Which Bonding Protocol Provides the Most Durable Zirconia Adhesion after In Vitr · 5/10 · Public Health
- 42605781 · Medication safety in older adults in India: an integrative PhD synthesis of dire · 5/10 · Public Health
💡 UNSOLICITED FINDS
- 42608373 · Effects of General Versus Regional Anaesthesia on Surgical Outcomes and Early Po · 8/10 ⚪ Promising but preliminary
- 42608319 · Glycated Albumin Guided Therapy in Newly Diagnosed Type 2 Diabetes A Randomized · 8/10 ⚪ Promising but preliminary
- 42608299 · [Preventive effect of Saccharomyces boulardii combined with Bifidobacterium quad · 8/10 🟢 Near-term implementable finding
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 13
- Diagnostics: 6
- Prevention: 5
- Drug Development: 5
- Early Detection: 4
- Other: 3
- Public Health: 3
- Genomics/Precision Medicine: 3 By evidence maturity:
- Exploratory: 20
- Validated: 14
- Potentially Practice-Changing: 8 By watchlist topic (candidates reviewed / highest score):
- Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma): 15 reviewed, 0 HIGH, 14 STANDARD, highest 7/10
- CBC-based diagnostics and machine learning in hematology: 0 reviewed, 0 HIGH, 0 STANDARD, highest 0/10
- Early cancer detection (liquid biopsy, ctDNA, cfDNA): 4 reviewed, 4 HIGH, 0 STANDARD, highest 7/10
- AI/ML in clinical diagnostics and imaging: 15 reviewed, 0 HIGH, 12 STANDARD, highest 6/10
- Precision oncology and genomic medicine: 15 reviewed, 1 HIGH, 13 STANDARD, highest 7/10
- Novel therapeutics: immunotherapy, CAR-T, targeted therapy: 15 reviewed, 3 HIGH, 12 STANDARD, highest 7/10
- Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk: 15 reviewed, 0 HIGH, 13 STANDARD, highest 7/10
- Aging, longevity, and population health: 15 reviewed, 0 HIGH, 8 STANDARD, highest 6/10
- Rare diseases with high unmet need: 5 reviewed, 5 HIGH, 0 STANDARD, highest 7/10
- Sentinel scan: 10 reviewed, 3 HIGH, 6 STANDARD, highest 8/10 By source type: peer_reviewed 42 | preprint 0 Topics with zero high-priority signal: Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma), AI/ML in clinical diagnostics and imaging, Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk, Aging, longevity, and population health
🔧 RUN NOTES
- T2 (CBC/ML hematology): zero results on both primary and fallback queries in CRDT window 2026/08/17–2026/08/18.
- run_status=PARTIAL_SUCCESS: T2 had 0 candidates reviewed; all other 9 topics complete.
- Attempt 2 of 3; attempt 1 failed due to provider/timeout failure with no output files generated.
- 102 unique PMIDs fetched via XML across all topics; 96/102 had extractable abstracts.
- T2 (CBC/ML): Primary and fallback queries both returned 0 results in this CRDT window.
- No 48h window expansion: other topics produced ≥5 relevant records.
- 102 unique PMIDs fetched via XML across 9 active topics; 96/102 had extractable abstracts.
- 42 articles retained in output (14 HIGH, 28 STANDARD).
- Sentinel scan reviewed 10 PMIDs; 3 unsolicited finds retained.