CAR-FIT: CAR-T fitness index for therapy - integrating comorbidity and geriatric assessments to guide safe and equitable delivery of CAR-T in patients with borderline physiological reserve.
A fitness-assessment tool successfully identified which borderline-health lymphoma patients would tolerate CAR-T therapy best, addressing a gap in treatment eligibility decisions.
This real-world study of 80 DLBCL patients demonstrates a composite CAR-FIT index significantly stratifies 1-year OS and PFS outcomes, enabling objective triaging of borderline-fit patients for CAR-T therapy. The tool addresses a critical gap in objective CAR-T eligibility criteria for patients with borderline physiological reserve.
What the study was
- Study design
- Real-world retrospective cohort; 80 relapsed DLBCL patients; CAR-FIT index combining CIRS, Severe4, CTCI, ECOG, Karnofsky scores.
- Population
- 80 relapsed/refractory DLBCL patients treated with CAR-T 2020-2025 (Singapore).
- Sample size
- 80
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Transplantation and Cellular Therapy
Why it surfaced
Practical validated fitness index for equitable CAR-T access in DLBCL; addresses critical gap in patient selection for borderline-fit patients.
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