Translating single-cell RNA sequencing into monocyte direct leukocyte subpopulation-transcript abundance assay ratio-based biomarkers (IFI27/PSAP or IFI27/CTSS) for clinical detection of viral infection
Two simple blood markers distinguish viral from bacterial infections, bridging laboratory discovery to a rapid bedside test for guiding appropriate antibiotic use.
Single-cell RNA sequencing analysis of monocyte subpopulations identified two leukocyte transcript abundance ratios—IFI27/PSAP and IFI27/CTSS—that discriminate viral from non-viral infection and were clinically validated in a translational study. This work bridges single-cell discovery directly to a simple deployable blood test, addressing a critical gap in rapid viral versus bacterial infection discrimination.
What the study was
- Study design
- translational_validation_study
- Population
- Patients with viral and non-viral infection evaluated for rapid discrimination
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Pathology
Why it surfaced
Pathology journal; high novelty: systematic bridge from scRNA-seq discovery to clinically deployable blood ratio test; addresses gap in rapid viral vs bacterial infection discrimination using blood leukocyte subpopulation profiling; methodology broadly applicable
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