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29 papers read · 26 surfaced · 11 stood out
Today's lead · hematologic_malignancies
Venetoclax in combination with cytarabine with or without idarubicin…
More than half of children with relapsed leukemia achieved complete remission with a venetoclax-chemotherapy combination, with most clearing detectable cancer cells.
Daniels KP, Pounds SB, Wu H et al. · Lancet Haematol
10/10
Impact score
Time to impact (est.)
- Lab
- Preclinical
- Early trials
- Late trials
- In practice
Promising but preliminary
Neuropsychiatric Outcomes With Tirzepatide, Semaglutide, and Other…
Two newer diabetes drugs show equivalent psychiatric safety while one demonstrates substantially lower suicide-related events than older alternatives.
Promising but preliminaryDynamic immune profiling predicts response to radiation plus…
Immune cell patterns in blood and tumors can predict which kidney cancer patients will respond to radiation plus immunotherapy.
Early cancer detection or preventionPhase II study of trastuzumab-pkrb plus gedatolisib in patients with…
Targeting a dual pathway escape mechanism in advanced breast cancer produced responses in 43% of heavily pretreated patients with specific mutations.
Promising but preliminaryGermline Multigene Panel Testing in Women With Invasive Lobular Cancer
Genetic testing reveals that lobular breast cancer patients with mutations in key genes face much higher recurrence risk, informing closer monitoring.