Considering Tumour Sidedness is Critical for Accurate Interpretation of Liquid Biopsy Results in Metastatic Colorectal Cancer.
Where the tumor originated affects how to interpret blood-based cancer biomarkers, requiring location-specific interpretation for better accuracy.
In 232 metastatic CRC patients, tumour sidedness was found to critically modulate the prognostic significance of liquid biopsy biomarkers including circulating RAS mutations, cfDNA concentration, and mutant allele fraction. This finding has immediate practical implications for how ctDNA/cfDNA results should be interpreted clinically, requiring stratification by primary tumor location.
What the study was
- Study design
- Prospective cohort study
- Population
- Metastatic colorectal cancer patients
- Sample size
- 232
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Molecular Diagnosis & Therapy
Why it surfaced
Important methodological insight for liquid biopsy interpretation in CRC: sidedness modulates biomarker prognostic value. Immediately relevant for clinical ctDNA assay interpretation.
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