Non-myeloablative versus reduced intensity conditioning for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia patients aged ≥65: a study from the ALWP of EBMT.
Choosing peripheral blood stem cells over bone marrow grafts may improve survival odds for older patients with AML undergoing transplant.
This large EBMT registry study of 2900 elderly AML patients found no significant survival difference between reduced-intensity and non-myeloablative conditioning for allogeneic transplantation. The finding that PBSC grafts confer a survival advantage over bone marrow in this population has immediate implications for graft source selection in older AML patients.
What the study was
- Study design
- Retrospective registry study (EBMT ALWP)
- Population
- AML patients aged ≥65 in complete remission undergoing allo-HCT
- Sample size
- 2900
- Category
- Treatment Innovation
- Maturity
- Potentially Practice-Changing
- Journal
- Bone Marrow Transplantation
Why it surfaced
Largest comparative study of conditioning intensity in elderly AML allotx (n=2900, EBMT registry); directly informs graft source and conditioning selection. PBSC advantage finding is ready for practice consideration pending prospective confirmation.
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