Association between the triglyceride-glucose index and kidney stone disease: a systematic review and dose-response meta-analysis
A simple blood-sugar marker linked to insulin resistance predicts kidney stone risk and may help doctors identify people who need preventive screening.
Meta-analysis of 14 studies (n=1,066,215) demonstrates a robust linear association between the TyG index (a surrogate for insulin resistance) and kidney stone disease, with each unit increase in TyG conferring 26-33% higher odds of KSD. The TyG index, derived from routine triglyceride and glucose measurements, offers a simple metabolic risk marker for KSD that could be incorporated into cardiometabolic risk screening.
What the study was
- Study design
- Systematic review and meta-analysis
- Population
- Adults in 14 observational studies
- Sample size
- 1066215
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Lipids in Health and Disease
Why it surfaced
Large meta-analysis with dose-response validation; TyG derived from routine labs; actionable for cardiometabolic risk counseling. Scored 5 due to KSD being peripheral to primary watchlist focus.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.