Circular RNAs in tumor biology and immunology: molecular mechanisms and therapeutic implications
Ring-shaped RNA molecules in blood show promise as non-invasive cancer markers and potential engineered therapeutics complementing existing liquid biopsy approaches.
This comprehensive review in Molecular Cancer covers circRNA biogenesis, their roles in cancer progression and immune evasion through TME modulation, and their dual potential as non-invasive liquid biopsy biomarkers and engineered therapeutic vehicles. The stability of circRNAs in plasma positions them as a complementary cfDNA biomarker class with growing translational relevance.
What the study was
- Study design
- Narrative review
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Molecular Cancer
Why it surfaced
High-impact journal (Mol Cancer). circRNA is an emerging biomarker class complementary to ctDNA/cfDNA. Score limited by review-only design.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.