Optimized PET/CT response assessment for prognostic stratification compared with Lugano criteria in extranodal NK/T-Cell lymphoma
Refined PET imaging criteria better predict which lymphoma patients will relapse, enabling early treatment adjustments to improve outcomes.
A multicenter retrospective study of 259 ENKTL patients developed and validated novel PET/CT response criteria (IPN) combining interim PET/CT referencing and nasal mucosal uptake as threshold, achieving superior prognostic discrimination (highest C-index for PFS and OS) compared to the widely-used Lugano classification. These criteria enable early identification of high-risk ENKTL patients and could guide treatment intensification or de-escalation decisions.
What the study was
- Study design
- Retrospective multicenter cohort
- Population
- Extranodal NK/T-cell lymphoma (ENKTL) patients at Ruijin Hospital and West China Hospital
- Sample size
- 259
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
Why it surfaced
Well-powered multicenter study (n=259) providing validated improvement over Lugano criteria for ENKTL response assessment — a rare aggressive lymphoma needing better prognostic tools; dual-center China collaboration
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