📅 PUBMED DAILY TRIAGE — 2026-05-26
Window: 2026-05-25T09:00:00Z → 2026-05-26T09:00:00Z (CRDT) Topics scanned: 10 | Candidates evaluated: ~78 | Articles classified: 16 High priority: 3 | Standard: 13 | Low/archive: 60+ | Unsolicited finds: 0 Run status: ✅ SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Precision Oncology & Genomic Medicine (highest-scoring article today)
TR-2026-05-26-003 · PMID 42185625 · Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE Koyama S, Natarajan P et al. (VA Million Veteran Program) · Nature Genetics → Landmark ExWAS in 1.16M individuals from diverse ancestries; identifies rare and common coding variants for blood lipids, maps novel drug targets, and substantially improves CV risk stratification across populations. Largest lipid genomics study to date.
Novel Therapeutics: CAR-T / Hematologic Malignancies
TR-2026-05-26-001 · PMID 42185808 · Efficacy and safety of CD30-targeted CAR-T cell therapy for lymphoma: a meta-analysis · 8/10 🟠 NOVEL_TREATMENT Shi J, Lu C, Song C, Wang Q · BMC Cancer → Meta-analysis synthesizes pooled efficacy and safety data for CD30-directed CAR-T in lymphoma, providing the strongest aggregated evidence to date for this targeted cellular immunotherapy approach.
Early Cancer Detection (Liquid Biopsy)
TR-2026-05-26-002 · PMID 42184714 · Diagnostic performance of urinary tumor DNA in urothelial carcinoma: A systematic review and network meta-analysis · 8/10 🔴 EARLY_CANCER_DETECTION Yajima S, Masuda H et al. · Urologic Oncology → Network meta-analysis comparing multiple urinary tumor DNA assays for non-invasive urothelial cancer detection; establishes comparative diagnostic accuracy to support clinical adoption of liquid biopsy for bladder/upper tract cancers.
Topics with NO high-priority articles today:
- CBC-based diagnostics and ML in hematology: No high-priority finds today (best candidate: PMID 42185576, 5/10) — 9th+ consecutive sparse run
- AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate: PMID 42185659 via cross-match, 7/10)
- Cardiovascular-metabolic (GLP-1/SGLT2): No high-priority finds today (best candidate: PMID 42185476, 7/10)
- Aging, longevity, and population health: No high-priority finds today (best candidate: PMID 42185655, 6/10)
- Rare diseases with high unmet need: No high-priority finds today (best candidate: PMID 42185862, 5/10)
🟢⚪ STANDARD (5–7) — Top by Topic
Early Cancer Detection (Liquid Biopsy / ctDNA / cfDNA)
- TR-2026-05-26-004 · PMID 42185659 · Liquid biopsy in distinguishing true progression from radiation necrosis in brain tumors · 7/10 · Early Detection (Systematic Review, J Neuro-Oncology)
- TR-2026-05-26-006 · PMID 42185453 · cfMeDIP-seq in oncology: technological advances to clinical applications · 6/10 · Early Detection (Review, NPJ Precision Oncology)
- TR-2026-05-26-010 · PMID 42185640 · Liquid biopsy genomic risk score to predict neurologic death in NSCLC · 6/10 · Diagnostics (J Neuro-Oncology)
Cardiovascular-Metabolic
- TR-2026-05-26-005 · PMID 42185476 · Physical activity and cardiometabolic diseases in association with cancer risk · 7/10 · Prevention (Prospective, Communications Medicine)
- TR-2026-05-26-009 · PMID 42185046 · Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes · 6/10 · Drug Development (Review, Br J Pharmacology)
- TR-2026-05-26-016 · PMID 42184906 · GLP-1 receptor agonists at crossroads of obesity and addiction · 5/10 · Drug Development (Review, Pharmacol Biochem Behav)
Hematologic Malignancies
- TR-2026-05-26-011 · PMID 42185479 · Copper depletion boosts CNS leukemia therapy (Nat Cancer) · 5/10 ⚠️ non-human cap · Treatment Innovation (Nat Cancer — Phase 2 full-text recommended)
- TR-2026-05-26-012 · PMID 42185854 · TIE-2 levels in newly diagnosed multiple myeloma · 5/10 · Diagnostics (BMC Cancer)
Novel Therapeutics
- TR-2026-05-26-008 · PMID 42185502 · TP53-mutated biliary tract cancer: enhanced ICI efficacy · 6/10 · Treatment Innovation (J Gastroenterology)
Precision Oncology / Genomic Medicine
(Top article already classified HIGH — see above)
Aging / Longevity
- TR-2026-05-26-007 · PMID 42185655 · Single-cell eQTL Mendelian randomization identifies immune cell regulators of epigenetic aging · 6/10 · Genomics/Precision Medicine (Biogerontology)
- TR-2026-05-26-013 · PMID 42185689 · Frailty impact on outcomes after robotic radical prostatectomy — multicenter · 5/10 · Treatment Innovation (J Robotic Surgery)
CBC / ML Hematology
- TR-2026-05-26-014 · PMID 42185576 · Thrombocytopenia and Plasmodium falciparum in Ghana · 5/10 🟡 UNDERSERVED_POPULATION · Diagnostics (Sci Rep)
Rare Diseases
- TR-2026-05-26-015 · PMID 42185862 · Orphan drug designation framework construction in China · 5/10 🟡 UNDERSERVED_POPULATION · Public Health (Orphanet J Rare Dis)
💡 UNSOLICITED FINDS
None today. Sentinel scan (n=1,957 total results reviewed top-10) produced no new out-of-watchlist high-signal articles beyond watchlist matches.
📊 TODAY'S BREAKDOWN
By research category:
- Early Detection: 3
- Treatment Innovation: 4
- Prevention: 1
- Diagnostics: 4
- Drug Development: 2
- Genomics/Precision Medicine: 2
By evidence maturity:
- Validated: 3 (all HIGH articles)
- Exploratory: 13
By watchlist topic (reviewed → kept → highest score):
| Topic | Reviewed | Kept | Best Score |
|---|---|---|---|
| Hematologic malignancies | 10 | 4 | 8 ✅ |
| CBC/ML hematology | 4 | 1 | 5 |
| Early cancer detection | 10 | 5 | 8 ✅ |
| AI/ML diagnostics | 10 | 3 | 7 |
| Precision oncology/genomics | 10 | 3 | 9 ✅ |
| Novel therapeutics | 10 | 2 | 8 ✅ |
| Cardiovascular-metabolic | 10 | 3 | 7 |
| Aging/longevity | 10 | 2 | 6 |
| Rare diseases | 10 | 1 | 5 |
| Sentinel scan | 10 | 0 | 4 |
By source type:
- Peer reviewed: 16 | Preprint: 0
Topics with zero 8+ articles today: CBC/ML hematology, AI/ML diagnostics, Cardiovascular-metabolic, Aging/longevity, Rare diseases, Sentinel
🔧 RUN NOTES
- Window: CRDT incremental — 2026-05-25T09:00Z → 2026-05-26T09:00Z. No expansion needed (>5 relevant records found).
- CBC/ML hematology sparse run (9th+ consecutive): Only 4 raw search results. None are pure CBC+ML/AI articles. Best result (PMID 42185576) is CBC-adjacent (thrombocytopenia in malaria context). Consider broadening search to "blood cell count AND clinical decision" or reviewing if hematology analyzers/AI-CBC tools are indexed under different terms.
- AI/ML diagnostics: 156 raw results but only 3 met quality threshold after filtering out animal models, non-human studies, and engineering-only papers. Human-validated AI diagnostic papers remain sparse — 5th+ consecutive run below threshold.
- Copper/CNS leukemia (PMID 42185479, Nat Cancer): Scored 5/10 per non-human cap but warrants Phase 2 review. Silverman LB and Cole PD (pediatric hematology leads) suggest translational/clinical components may be present in full text.
- Aging human filter working: humans[MeSH] successfully excluded non-human studies (C. elegans, rodent models) that inflated previous runs.
- Truncation: Sentinel (1,957 results), Novel therapeutics (605), Precision oncology (661), AI/ML (156) all exceeded cap. Top-10 reviewed per topic per protocol.
- Previous run (2026-05-25) PMIDs confirmed as non-overlapping: All today's PMIDs (range ~42184xxx–42185xxx) are new vs. prior run (range ~42177xxx–42178xxx).
- Alert deduplication: 3 new HIGH alerts — none previously emitted.