Genome-wide variation in cell-free DNA end motif entropy predicts…
A blood test measuring DNA fragment patterns could help doctors predict which head-and-neck cancer patients will respond to immunotherapy, independent of current protein markers.
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Interpretable fine-tuned large language models facilitate making…
AI that explains its reasoning step-by-step helps doctors decide whether rare disease patients need targeted or whole-genome sequencing, improving diagnostic accuracy.
Novel or significantly improved treatmentDevelopment and validation of artificial intelligence-based model for…
AI analyzing routine pathology slides can identify bladder cancer types most likely to respond to immunotherapy, faster and more consistently than pathologists alone.
Novel or significantly improved treatmentPhase Ib of repotrectinib plus osimertinib in patients with…
A drug combination shows promise in lung cancer patients who've stopped responding to standard treatment, offering a concrete option for an otherwise difficult-to-treat group.
Underserved or high-risk populationsEffect of tiomolibdate choline on copper balance in patients with…
An oral copper-reducing drug rapidly restores healthy copper balance in Wilson disease patients, expanding limited treatment options for this rare disorder.