📅 PUBMED DAILY TRIAGE — 2026-05-14
Window: 2026-05-13T09:00:00Z → 2026-05-14T09:00:00Z (CRDT) Topics scanned: 10 | Candidates reviewed: ~80 | Deferred PMIDs processed: 3 High priority: 0 | Standard: 22 | Low/archive: ~58 (count-only) | Unsolicited finds: 2 Run status: ✅ SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
No HIGH priority articles this run. Best candidate per topic listed below.
| Topic | Best PMID | Score |
|---|---|---|
| Hematologic malignancies | 42122157 EMD-AML n=617 | 7/10 |
| CBC/ML in hematology | 42119559 MKIDS ML megakaryocyte (Dev Cell) | 7/10 |
| Early cancer detection | 42128474 cfDNA sarcoma meta-analysis | 7/10 |
| AI/ML diagnostics | 42120994 CKD multimodal ML UKBB n=46,986 | 7/10 |
| Precision oncology | 42120994 (shared) | 7/10 |
| Novel therapeutics | 42124577 MUC4 CAR-T CRC preprint | 5/10 |
| GLP-1/SGLT2/cardiometabolic | 42121905 GLP-1 + Parkinson's | 5/10 |
| Aging/longevity | 42124461 Mitochondrial signaling + longevity | 4/10 |
| Rare diseases | 42128308 WWOX/WOREE + AAV gene therapy | 7/10 |
| Sentinel scan | 42123718 Monocyte transcriptomics CRC | 7/10 |
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies (AML, MDS, CLL, MPN, Lymphoma)
- 42122157 · Extramedullary AML: Clinical and Molecular Features · 7/10 · Diagnostics/Treatment — EMD-AML (n=617) shows dramatically worse OS (14.2 vs 64.1 mo); NPM1/t(8;21) enriched; PSM validated
- 42123622 · Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights · 5/10 · Treatment Innovation — Review: aging-driven clonal dynamics, niche remodeling → leukemogenesis
- 42126511 · Ferroptosis in Myelodysplastic Syndromes · 5/10 · Treatment Innovation — Review: GPX4/FRGs as novel therapeutic targets in transfusion iron-overloaded MDS
- 42122287 · CAR-T Prospects in Myelofibrosis · 5/10 · Treatment Innovation — Review: CD123/MPL/FAP/TGF-β targets; dual clonal+fibrotic microenvironment strategy
- 42122154 · Immunotherapy in NK/T-Cell Lymphoma · 5/10 · Treatment Innovation — Review: PD-1/PD-L1 active but EBV resistance mechanisms limit durability; multimodal emerging
CBC-Based Diagnostics and ML in Hematology
- 42119559 · ML-based Megakaryocyte Identification System (MKIDS) · 7/10 · Diagnostics — scRNA-seq + ML reveals brain/heart/placenta-resident MKs in humans; Tnik novel marker [DEFERRED 5/13]
- 42121076 · SII (CBC composite) for ED Outcomes · 5/10 · Diagnostics — SII adds to NEWS2 (AUC 0.717→0.758 hospitalisation); n=6,739
Early Cancer Detection (Liquid Biopsy, ctDNA, cfDNA)
- 42128474 · Liquid Biopsy in Sarcoma: Systematic Review & Meta-analysis · 7/10 · Early Detection — cfDNA+ → OS HR 1.82, DFS HR 2.23; 9 studies; first quantitative prognostic evidence
- 42122234 · Liquid Biopsy for Genomic Profiling & MRD in Multiple Myeloma · 5/10 · Diagnostics — Review: ctDNA/CTCs capture spatial heterogeneity; MRD monitoring focus
- 42122162 · Liquid Biopsy in Advanced Prostate Cancer · 5/10 · Diagnostics — Review: BRCA1/2 actionable mutations; clonal hematopoiesis as key false-positive confounder
AI/ML in Clinical Diagnostics and Imaging
- 42120994 · Multimodal ML for ESRD Prediction; Novel Genomic Biomarkers · 7/10 · Diagnostics — UK Biobank n=46,986; AUC 0.804; novel SNP rs1383063 (MAGI-1) in 30% of population [DEFERRED 5/13]
- 42120992 · HR-VWI Radiomics for Intracranial Aneurysm Risk Stratification · 6/10 · Diagnostics — AUC 0.888 vs PHASES 0.679; two-center retrospective; n=446 [DEFERRED 5/13]
- 42123604 · AI Strategies for Mechanistic Cancer Target Discovery · 5/10 · Drug Development — Review: multi-omics + ML for synthetic lethality, de novo drug design
Precision Oncology and Genomic Medicine
- Shared articles with AI/ML and Hematology topics above (42120994, 42122157)
- Truncation note: top 7 candidates reviewed; batch truncation limited full coverage of 367 raw results
Novel Therapeutics (Immunotherapy, CAR-T, Targeted Therapy)
- 42124577 · MUC4-targeted CAR-T Cells for Chemoresistant Colorectal Cancer [PREPRINT] · 5/10 · Treatment Innovation — Preclinical: eliminates HT29-MTX/T84 in vitro; reduces tumor burden in aggressive IP CRC model; no off-target toxicity
- 42122287 · CAR-T in Myelofibrosis (see Hematology section) · 5/10
- 42122154 · Immunotherapy in NK/T-Cell Lymphoma (see Hematology section) · 5/10
Cardiovascular-Metabolic (GLP-1, SGLT2, Cardiometabolic)
- 42121905 · GLP-1 and Parkinson's Disease: Biology, Mechanisms, Efficacy · 5/10 · Treatment Innovation — Review (UCL): GLP-1R → α-synuclein/dopamine pathways; early-phase CNS engagement evidence
- 42123472 · GLP-1 Receptor Agonists in Type 1 Diabetes: Umbrella Review · 5/10 · Treatment Innovation — Weight loss -4.35 to -5.1 kg; modest HbA1c -0.2-0.3%; CV benefit unproven in T1DM
- 42123553 · Antidiabetic Therapies in MCI/Alzheimer's: Systematic Review · 5/10 · Treatment Innovation — Metformin: episodic memory benefit in early AD; GLP-1 RA evidence insufficient; 11 studies
- 42122936 · GLP-1 RA Fertility & Reproductive Safety in Women: Narrative Review · 5/10 · Prevention — GLP-1 RAs may improve ovulation in PCOS/obesity; reproductive safety during pregnancy inadequately characterized
Aging, Longevity, and Population Health
- 42124461 · Mitochondrial Signaling and Stress Responses in Aging · 4/10 · Other — Review: ROS dual role; UPR^MT, ISR pathways; mitohormesis concept; therapeutic target overview
- No high-priority aging finds today (best candidate scored 4/10)
Rare Diseases with High Unmet Need
- 42128308 · WWOX in Brain Development and WOREE Syndrome: Therapeutic Opportunities · 7/10 · Treatment Innovation — Review: AAV-based WWOX replacement rescues seizures/myelination/survival in preclinical; clear gene therapy roadmap for fatal ultra-rare NDD
- 42122051 · Disorders Mimicking Wilson's Disease: Differential Diagnosis · 5/10 · Diagnostics — Review: ATP7A, MEDNIK, aceruloplasminemia, glycosylation disorders; misdiagnosis → harmful anti-copper therapy
- 42124386 · Muscle Stiffness due to Neuromuscular Hyperexcitability · 4/10 · Diagnostics — Review: rare myopathies (Rippling MD, Brody); stiff-person, Isaacs, Morvan syndromes
💡 UNSOLICITED FINDS
From Sentinel Scan — High Signal Out-of-Watchlist
42123718 (7/10) · Systematic Review: Monocyte Transcriptomic Profiles for CRC Early Detection · Int J Mol Sci · PROSPERO-registered; 6 studies; CXCR2+ monocytes and m6A/m5C epitranscriptomic marks outperform classical biomarkers for CRC detection in some studies. Relevance: adjacent to liquid biopsy/early detection watchlist; novel non-invasive immune-cell transcriptomic approach. Consider adding to watchlist.
42122026 (6/10) · Girentuximab PET-CT for Clear-Cell Renal Cell Carcinoma · Diagnostics · ZIRCON phase 3 trial evidence: sensitivity 85%, specificity 87%; >96% for lesions <2 cm. Relevance: near-term implementable molecular imaging for a common cancer; phase 3 evidence reviewed. Pipeline-ready for early detection topic.
📊 TODAY'S BREAKDOWN
By research category:
- Diagnostics: 9
- Treatment Innovation: 9
- Early Detection: 4
- Prevention: 2
- Drug Development: 1
- Public Health: 1
- Other: 1
By evidence maturity:
- Exploratory: 21
- Validated: 2 (42128474 meta-analysis sarcoma cfDNA; 42122026 ZIRCON phase 3 review)
By watchlist topic (reviewed / kept / highest score):
| Topic | Reviewed | Kept | Best Score |
|---|---|---|---|
| Hematologic malignancies | 10 | 5 | 7 |
| CBC/ML hematology | 5 | 2 | 7 |
| Early cancer detection | 10 | 3 | 7 |
| AI/ML diagnostics | 8 | 4 | 7 |
| Precision oncology | 7 | 2 | 7 |
| Novel therapeutics | 7 | 3 | 5 |
| GLP-1/cardiometabolic | 8 | 4 | 5 |
| Aging/longevity | 8 | 1 | 4 |
| Rare diseases | 7 | 3 | 7 |
| Sentinel scan | 10 | 2 | 7 |
By source type:
- Peer-reviewed: 21
- Preprint: 1 (42124577 bioRxiv)
Topics with zero 8+ articles this run: ALL TOPICS (no HIGH priority articles today)
🔧 RUN NOTES
- Deferred PMIDs processed: 42119559 (Dev Cell MKIDS megakaryocyte ML), 42120994 (BMC Nephrol multimodal ESRD), 42120992 (BMC Med Imaging radiomics aneurysm) — all 3 successfully retrieved and classified this run.
- Window expansion: NOT triggered (>5 relevant records found).
- Truncation: efetch batch responses capped at ~20KB, limiting multi-article batch coverage. Precision oncology topic partially covered; additional candidates in 367-result set not retrieved. No records silently dropped — truncation documented in search_logs.
- Aging/longevity: humans[MeSH] filter applied per 2026-05-04 standing instruction. 88 results (healthy improvement from prior non-human noise). Only 1 abstract retrieved from batch due to efetch truncation.
- Publication pattern today: Heavy Cancers (Basel) and Int J Mol Sci mega-issue output driving high raw counts in cancer/immunotherapy/GLP-1 topics; most articles are review-type with low design quality scores.
- Telegram alerts: SUPPRESSED — no HIGH priority (≥8) articles found. Per protocol, no alerts sent when no HIGH articles identified.
- Rolling 7-day note: Aging/longevity topic has produced no 8+ articles this run (consistent with prior runs). GLP-1/cardiometabolic and Novel therapeutics also produced no HIGH articles today. Hematologic malignancies remains the most productive topic for STANDARD-range articles.
- COI flag: PMID 42119559 (MKIDS) — HaemoCure Inc. shareholders among authors; note for downstream pipeline.