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25 papers read · 25 surfaced · 5 stood out
Today's lead · Treatment Innovation
CRISPR-Cas9 CD33-deleted allogeneic hematopoietic cell…
CRISPR-edited donor cells without CD33 can safely engraft and tolerate targeted therapy, offering a new way to treat blood cancers after transplant.
DiPersio JF, Koehne G, Shah NN et al. · Nature Medicine
9/10
Impact score
Time to impact (est.)
- Lab
- Preclinical
- Early trials
- Late trials
- In practice
Near-term implementable finding
Orforglipron for maintenance of body weight reduction
An oral pill maintains weight loss achieved by injectable therapy, potentially making long-term obesity treatment more accessible globally.
Underserved or high-risk populationsUnprocessed U1 snRNAs as a biomarker of INTS11- and BRAT1-related…
Unprocessed RNA accumulation offers a measurable biomarker to identify disease severity in rare genetic neurological conditions and guide treatment decisions.
Novel or significantly improved treatmentAdjuvant personalized multivalent neoantigen DNA vaccination for MGMT…
A personalized cancer vaccine triggered immune responses in most patients and helped one person with aggressive brain cancer survive four years.
Novel or significantly improved treatmentPasteurized Akkermansia muciniphila MucT for weight loss maintenance…
A daily probiotic supplement significantly reduces weight regain after diet-induced weight loss, offering a non-drug maintenance approach.