Lactylation and liquid-liquid phase separation related genes influence prognosis and immune characteristics of diffuse large B-cell lymphoma patients
Four genetic markers in blood cancer patients predict outcomes and connect to immune patterns, offering a testable lead for future treatment strategies.
Four lactylation/liquid-liquid phase separation-related genes were identified as DLBCL prognostic markers, with a risk model validated in 1310 patients and correlation to immune microenvironment features. The study is exploratory and bioinformatics-driven, but the validated N and immune relevance make it a candidate for downstream experimental testing.
What the study was
- Study design
- Bioinformatics prognostic model construction and validation (multi-dataset GEO/bulk RNA-seq)
- Population
- DLBCL patients (GSE56315, GSE10846 N=414, external validation GSE181063 N=1310)
- Sample size
- 1724
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Hematology (Amsterdam, Netherlands)
Why it surfaced
Bioinformatics DLBCL prognostic model with large validation cohort; exploratory but well-executed; no experimental validation or clinical prospective design.
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