MicroRNA-mRNA Regulatory Network Associated with Cognitive Impairment in Multiple Sclerosis
Blood microRNA patterns distinguish multiple sclerosis patients with cognitive problems, potentially enabling earlier detection and targeted cognitive support.
In 46 people with MS, miR-146a-5p, let-7a-5p, and miR-21-5p were significantly dysregulated in those with cognitive impairment compared to preserved cognition, pointing to a miRNA-based blood biomarker signature for MS-related cognitive dysfunction. Target network analysis implicated inflammatory cytokines (IL-1B, IL-6) and neurofilament light chain (NEFL) as key downstream effectors.
What the study was
- Study design
- Observational biomarker study with miRNA profiling (PCR panel + RT-qPCR) in a clinical cohort
- Population
- People with multiple sclerosis (N=46)
- Sample size
- 46
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Molecular Neurobiology
Why it surfaced
Outside primary watchlist (MS neurology, not hematology/oncology/cardiometabolic). Small N (46), exploratory miRNA biomarker study. Interesting methodologically but not a priority for this pipeline.
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