Efficacy and safety of N-acetylcysteine in patients with mild cognitive impairment undergoing exercise-based cardiac rehabilitation program: a randomized controlled trial
Adding an inexpensive antioxidant to heart-rehab exercise may enhance memory recovery in people with mild cognitive impairment, combining two affordable approaches.
This CIHR-funded RCT from Sunnybrook Research Institute investigates whether N-acetylcysteine, an antioxidant targeting oxidative stress and mitochondrial function, augments cognitive benefits of exercise-based cardiac rehabilitation in patients with mild cognitive impairment. The combination approach targets both vascular and metabolic mechanisms of cognitive decline, potentially offering a low-cost adjunctive strategy for a highly prevalent at-risk population.
What the study was
- Study design
- Randomized controlled trial
- Population
- Adults with mild cognitive impairment undergoing exercise-based cardiac rehabilitation
- Category
- Prevention
- Maturity
- Validated
- Journal
- Alzheimer's Research & Therapy
Why it surfaced
RCT design; addresses unmet need in MCI prevention/treatment; novel combination of antioxidant therapy with exercise rehabilitation; CIHR-funded high-quality Canadian trial.
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