📅 PUBMED DAILY TRIAGE — 2026-04-28

Window: 2026-04-27T09:00:00Z → 2026-04-28T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~70 candidates | Candidates evaluated: 15 (+ 1 sentinel placeholder) High priority: 1 | Standard: 9 | Low/archive: 5 | Unsolicited finds: 1 (unreviewed sentinel batch) Run status: PARTIAL_SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Aging, Longevity & Population Health

TR-2026-04-28-001 / PMID 42045785 · Modification of the association between age and mortality in heart failure by frailty status · 9/10 🟢 NEAR_TERM_IMPLEMENTABLE

Danish nationwide registry (N=79,193 HF patients, 2013-2022): frailty telescopes 33 years of biological aging — a high-frailty 47-year-old has the same 2-year mortality (~22%) as a low-frailty 80-year-old. GDMT significantly underused in frail patients across all age groups. Direct implications for HF management stratification by frailty rather than age alone.

Hematologic Malignancies

No high-priority finds today (best candidate scored 7/10 — see STANDARD section)

Early Cancer Detection

No high-priority finds today (best candidate scored 7/10)

AI/ML in Clinical Diagnostics

No high-priority finds today (coverage partial due to batch truncation)

Precision Oncology

No high-priority finds today (best candidate scored 5/10)

Novel Therapeutics

No high-priority finds today (best candidate scored 5/10)

Cardiovascular-Metabolic

Partial coverage; best abstract scored 5/10 (cardiometabolic batch truncated)

CBC-Based Diagnostics / ML Hematology

No high-priority finds today (fifth consecutive sparse run; see Run Notes)

Rare Diseases

No articles reviewed today (topic deferred; see Run Notes)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic Malignancies

• TR-2026-04-28-002 / PMID 42045698 · EBUS sampling for mediastinal/hilar lymphadenopathy: network meta-analysis (N=2,357) · 7/10 · Diagnostics
  • EBUS-TBMC achieves 94.1% sensitivity for lymphoma vs only 40.8% for standard TBNA; TBMC+TBNA combination most effective overall
• TR-2026-04-28-004 / PMID 42045559 · CMML extramedullary disease: biology, patterns, and management (Leukemia review) · 6/10 · Treatment Innovation
  • 10-15% of CMML patients develop biopsy-proven EMD; RAS-MAPK enrichment, ASXL1 co-mutations, adverse OS; integrated PET-CT + clonality testing recommended
• TR-2026-04-28-007 / PMID 42045616 · Bilingual group coping intervention for cGVHD survivors (pilot RCT, N=21) · 5/10 · Underserved Population
  • Feasibility benchmarks met (52.5% enrollment, 95.2% retention) in predominantly Hispanic/Latino cGVHD cohort; supports larger trial

Early Cancer Detection / Liquid Biopsy

• TR-2026-04-28-003 / PMID 42045778 · NIPT for severe thalassemia using cfDNA + Bayesian model (prospective, N=442) · 7/10 · Diagnostics
  • 97.89% sensitivity, 98.56% specificity without parental haplotype; validates non-invasive prenatal testing in high-prevalence SEA carrier population
• TR-2026-04-28-005 / PMID 42045902 · ML integration of blood protein-metabolite profiles for NSCLC early detection · 6/10 · Early Detection
  • Proteomics + metabolomics + ML (SHAP) classifier for NSCLC; sample size not retrieved; Respiratory Research
• TR-2026-04-28-006 / PMID 42045780 · 24 HPV triage strategies compared in self-sampled HR-HPV+ women (N=777) · 6/10 · Early Detection
  • Strategies 3a and 5a: maintain 95% CIN3+ sensitivity, reduce colposcopy referral by 22% vs guideline standard

Novel Therapeutics / Precision Oncology

• TR-2026-04-28-008 / PMID 42045760 · SPP1+/CXCR4+ TAM crosstalk drives immunotherapy resistance in LUAD (multi-omics + spatial) · 5/10 · Treatment Innovation

Aging, Longevity & Population Health

• TR-2026-04-28-009 / PMID 42045819 · Postoperative delirium prediction from pre-operative cerebral SVD imaging markers · 5/10 · Diagnostics (elderly)
• TR-2026-04-28-010 / PMID 42045931 · LTC Needs Index for MENA aging populations (3-22.8% dependency range) · 5/10 · Public Health

💡 UNSOLICITED FINDS

No high-signal out-of-watchlist items confirmed. Sentinel scan top 10 PMIDs logged for review (abstracts not retrieved): 42045987, 42045982, 42045976, 42045971, 42045970, 42045968, 42045967, 42045961, 42045959, 42045958.

📊 TODAY'S BREAKDOWN

By research category:

• Early Detection: 3 | Diagnostics: 4 | Treatment Innovation: 3 | Public Health: 3 | Drug Development: 1 | Prevention: 1 | Other: 1

By evidence maturity:

• Validated: 4 | Exploratory: 11 | Potentially Practice-Changing: 0

By watchlist topic (reviewed / kept / highest score):

*CBC/ML PMIDs appear to predate window (PMID range mismatch) †Batch truncated; partial coverage only

By source type: peer_reviewed 15 | preprint 0

Topics with zero 8+ articles this run: Hematologic malignancies, CBC/ML hematology, Early cancer detection, AI/ML diagnostics, Precision oncology, Novel therapeutics, Cardiometabolic, Rare diseases

🔧 RUN NOTES

• Window expansion: NOT triggered (>5 relevant articles found)
• Truncation: YES — abstract retrieval batches truncated at 50KB limit. Affected topics: AI/ML diagnostics, Novel therapeutics, Cardiometabolic, Rare diseases. Batch cap is ~20 records per fetch; multiple articles per topic not fully reviewed.
• CBC/ML Hematology — fifth consecutive sparse run: API returned 9 PMIDs (42037715-42043348) that appear to predate the April 27 CRDT window based on PMID range. This suggests persistent CRDT indexing lag for this topic. Recommendation: broaden query to include "hematology analyzer", "WBC differential", "red cell distribution width", "platelet indices" for next run.
• Rare diseases topic: 140 raw results available but 0 abstracts reviewed due to batch cutoff. Top 10 PMIDs deferred: 42044937, 42044943, 42044980, 42045051, 42045154, 42045422, 42045567, 42045620, 42045739, 42045784.
• Sentinel scan: 3,302 raw candidates; top 10 PMIDs logged as unsolicited find placeholders; abstracts not retrieved.
• Errata excluded: PMID 42045901 (published erratum for AML paper).
• Rolling 7-day CBC/ML sparse runs: 5 consecutive days with 0 or near-0 results in CRDT window; query restructuring required for next run.