📅 PUBMED DAILY TRIAGE — 2026-04-26

Window: 2026-04-25T09:00Z → 2026-04-26T09:00Z (CRDT primary) | Expanded: +2026-04-24T00:00Z (48h) Topics scanned: 10 | Articles reviewed (candidates): ~80+ across primary + expanded windows | Classifiable: 13 High priority: 0 | Standard: 12 | Low/archive: 1 | Unsolicited finds: 0 Run status: PARTIAL_SUCCESS

⚠️ RUN NOTE — Primary Window Metadata Outage

All 56 PMIDs from the primary CRDT window (2026-04-25 to 2026-04-26, IDs ~42032835–42033203) returned "cannot get document summary" from PubMed APIs and 404/empty via web — these are CRDT-indexed but not yet fully available for retrieval (known NCBI pipeline lag for very fresh records). 48-hour window expansion triggered per protocol. All 13 classified articles are from the April 24 CRDT window. Primary window IDs deferred to tomorrow's run.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic malignancies: No high-priority finds today (best candidate scored 5/10) CBC-based diagnostics and ML in hematology: No high-priority finds today (0 classifiable — topic sparse, third partial run) Early cancer detection (liquid biopsy, ctDNA, cfDNA): No high-priority finds today (best scored 6/10) AI/ML in clinical diagnostics and imaging: No high-priority finds today (best scored 6/10) Precision oncology and genomic medicine: No high-priority finds today (best scored 6/10) Novel therapeutics (immunotherapy, CAR-T, targeted therapy): No high-priority finds today (best scored 5/10) Cardiovascular-metabolic (GLP-1, SGLT2): No high-priority finds today (0 new classifiable) Aging, longevity, population health: No high-priority finds today (best scored 5/10) Rare diseases with high unmet need: No high-priority finds today (best scored 5/10) Sentinel: No high-priority unsolicited finds (all primary window IDs unretrievable)

ℹ️ No Telegram alerts sent — no HIGH priority articles this run.

🟢⚪ STANDARD (5-7) — Top by Topic

Early Cancer Detection / Liquid Biopsy

• TR-2026-04-26-001 · PMID 42026749 · Ando K et al. · Insect Olfactory Receptor-Expressing Sensor Cells for CRC Diagnosis Using Urine Samples · 6/10 · Early Detection

  • OR biosensor + ML achieves 80% sensitivity, AUC 0.84 for CRC from urine VOCs (n=150); PMC available

• TR-2026-04-26-002 · PMID 42026947 · Goy Y et al. · Circulating Tumor Cell Viability During and After Radiotherapy Mirrors Treatment Response · 6/10 · Diagnostics

  • CTC apoptotic rate is a liquid biopsy surrogate for RT response in lung+breast cancer (n=71)

• TR-2026-04-26-003 · PMID 42027195 · Holdhoff M et al. · Clinical Utility of Belay Summit 2.0 Cerebrospinal Fluid Test — Mixed Methods Study · 5/10 · Diagnostics ⚠️ COI

  • 74% positive genomic yield; 86% clinical utility in 49 CNS tumor cases; significant industry COI (Belay Diagnostics authors)

Precision Oncology / Genomic Medicine

• TR-2026-04-26-007 · PMID 42032759 · Kawasaki K et al. · Altered ER Signaling Pathway in BRCA2-Deficient ER+/HER2- Breast Cancer · 6/10 · Genomics/Precision Medicine

  • First characterization of ER signaling in BRCA2 germline ER+ breast cancer; BRCA2-KO cells show increased olaparib sensitivity; PMC available

• TR-2026-04-26-006 · PMID 42032753 · Xie Y et al. · Claudin18.2-Positive Gastric Cancer: Biology, TME, and Therapeutic Strategies · 5/10 · Treatment Innovation

  • Comprehensive review of CLDN18.2 (actionable target, zolbetuximab approved) and emerging agents in GC

• TR-2026-04-26-012 · PMID 42026773 · Muhammad Y et al. · Intrahepatic Cholangiocarcinoma: Epidemiology, Diagnosis, and Personalized Therapy · 5/10 · Treatment Innovation 🟡

  • Reviews rising global iCCA burden + FGFR2/IDH1/immune therapy landscape in this rare high-unmet-need cancer

AI/ML in Clinical Diagnostics

• TR-2026-04-26-010 · PMID 42032496 · Ren Y et al. · PALBI Score + ML for 30-Day Sepsis Mortality — MIMIC-IV Evidence · 6/10 · Diagnostics
  • MIMIC-IV-based ML model using platelet-albumin-bilirubin composite for ICU sepsis mortality prediction

Hematologic Malignancies

• TR-2026-04-26-004 · PMID 42031696 · Parikh R et al. · Diabetes Mellitus in Multiple Myeloma: Risk, Prognosis, and Outcomes · 5/10 · Treatment Innovation

  • MSK/Emory review of T2DM × MM intersection, overlapping toxicities, management gaps

• TR-2026-04-26-005 · PMID 42032324 · Takakuwa T et al. · Teclistamab for Pulmonary Extramedullary Myeloma: First Successful Case · 4/10 · Treatment Innovation ⚪

  • Case report (score capped at 4): first documented teclistamab response in extramedullary myeloma with pulmonary lesions

Novel Therapeutics

• TR-2026-04-26-008 · PMID 42032446 · Yan R et al. · DEE Induces Ferroptosis via SLC7A11 Inhibition in NSCLC · 5/10 · Drug Development

  • Novel p53-independent ferroptosis mechanism via SLC7A11 transport inhibition; in vivo efficacy ~ paclitaxel (preclinical)

• TR-2026-04-26-009 · PMID 42032366 · Yue T et al. · Stress Granules Promote DNA Repair via G3BP1/NAT10/ATF3 Axis in NPC · 5/10 · Drug Development

  • Novel ac4C-dependent SG-DNA repair axis in NPC (n=111 tissue); NAT10 inhibitor remodelin shows preclinical antitumor activity

Aging / Population Health

• TR-2026-04-26-011 · PMID 42032739 · Boscheck H et al. · Cognitive Reserve, Psychological Debt, and Alzheimer's Biomarkers — DELCODE Study · 5/10 · Prevention
  • Multi-site German DZNE cohort examining modifiable resilience factors vs AD biomarker burden

💡 UNSOLICITED FINDS

None this run. Primary window sentinel scan (132 raw, 10 reviewed) yielded 0 results due to metadata outage.

📊 TODAY'S BREAKDOWN

By research category:

• Early Detection: 1
• Diagnostics: 3
• Treatment Innovation: 4
• Drug Development: 2
• Genomics/Precision Medicine: 1
• Prevention: 1
• Public Health: 1 (dual-categorized)

By evidence maturity:

• Exploratory: 10
• Validated: 2

By watchlist topic (reviewed → kept → highest score):

*42026773 captured via cross-topic match

By source type: peer_reviewed: 13 | preprint: 0

By pipeline_priority: STANDARD: 12 | LOW: 1 | HIGH: 0

Topics with zero 8+ articles this run: ALL (no HIGH priority articles today)

🔧 RUN NOTES

• 48-HOUR WINDOW EXPANSION TRIGGERED — All 56 primary window PMIDs (April 25-26 CRDT) returned metadata errors. Expanded to April 24 CRDT. Log: error_type: CRDT_METADATA_LAG.
• Primary window deferred PMIDs (~56 IDs, range 42032835–42033203): These should be re-checked in next run's deduplication step; metadata likely available by then.
• CBC/ML hematology: Zero classifiable for 3rd partial consecutive run. Recommend broadening query to include: hemogram, leukocyte differential, morphology, cytometry. Action: update search string for tomorrow's run.
• Cardiovascular-metabolic (GLP-1/SGLT2): No new records in expanded window (all April 24 already emitted). Topic productively covered in recent runs — no coverage gap.
• Sentinel scan: Primary window 100% unretrievable. No sentinel finds.
• Rolling 7-day HIGH-priority view (from state): Last HIGH was PMID 42028006 (pan-cancer cfDNA methylation, Apr 25 run). Today: 0 HIGH. 2-day gap — within normal variation.
• Alert status: No OUTPUT C alerts sent — no HIGH priority articles found this run.