Senescence of T cells and organ aging
Aging immune cells contribute to organ aging including brain aging; multiple drug approaches targeting this process are now in early clinical trials.
This review synthesizes the molecular basis of T cell immunosenescence and its role in organ aging, highlighting the NR4a transcriptional network and links to brain aging including Alzheimer's disease. Multiple early-stage clinical interventions targeting T cell aging — including PD-1/PD-L1 blockade, mTOR inhibition, and mesenchymal stromal cell therapy — show potential for translation.
What the study was
- Study design
- Review
- Population
- General population (aging biology review)
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Inflammation and Regeneration
Why it surfaced
Solid review of T cell immunosenescence with clinical translation highlights; contributes to aging/longevity topic coverage.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.