Clinical Validation of Venetoclax Volumetric Microsampling in Patients with Leukemia with Assessment of Whole-Blood-to-Plasma Conversion Strategies and Self-Microsampling Feasibility
Home finger-prick blood sampling accurately monitors a key leukemia drug, enabling patients to skip frequent clinic visits.
Capillary microsampling with individualized hematocrit correction enables accurate venetoclax pharmacokinetic monitoring in AML and CLL patients, meeting international validation standards. Home-based self-sampling is feasible in 86% of patients, opening a path to decentralized PK monitoring for venetoclax dose optimization.
What the study was
- Study design
- Clinical validation study
- Population
- AML and CLL patients on oral venetoclax
- Sample size
- 25
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Clinical Pharmacokinetics
Why it surfaced
Practical clinical validation with real hematology patients; enabling decentralized PK monitoring for venetoclax is clinically meaningful.
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