📅 PUBMED DAILY TRIAGE — 2026-04-22

Window: 2026-04-21T09:00:00Z → 2026-04-22T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: ~80 candidates | Candidates evaluated: 22 fully scored High priority: 2 | Standard: 18 | Low/archive: 2 | Unsolicited finds: 0 Run status: SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Early Cancer Detection (Liquid Biopsy / ctDNA / cfDNA)

TR-2026-04-22-001 / PMID 42014803 · Nanoplate based digital PCR assay for effective quantification of plasma HPV circulating tumor DNA · 8/10 🔴 EARLY_CANCER_DETECTION

Validated prospective ctDNA assay (n=87, registered RCT) achieves 98% sensitivity / 100% specificity for HPV16/18/31 in cervical cancer; longitudinal ctDNA persistence reliably flags relapse.

TR-2026-04-22-002 / PMID 42013849 · Plasma extracellular vesicle proteomics nominates candidate biomarkers of ¹⁷⁷Lu-PSMA-617 outcomes in metastatic prostate cancer patients · 8/10 🟠 NOVEL_TREATMENT

First systematic EV proteomics study (5,137 proteins, 100 mCRPC patients) for ¹⁷⁷Lu-PSMA-617 outcome prediction; identifies druggable surface targets B7-H3, Trop-2, STEAP1; p53/E2F pathway correlates with PFS/OS.

🟢⚪ STANDARD (5–7) — Top by Topic

Hematologic Malignancies (AML, MDS, CLL, MPN, Lymphoma) — best score 6/10

• TR-003 / PMID 42014940 · MM Consensus Recommendations — 2025 Bridging the Gaps Conference · 6/10 · Treatment Innovation
• TR-008 / PMID 42014937 · Secondary solid malignancies in DLBCL vs FL (n=1,866, nomogram AUC 0.761) · 5/10 · Diagnostics
• TR-009 / PMID 42014876 · Chidamide + cisplatin/etoposide triggers pyroptosis via GSDME in DLBCL (preclinical) · 5/10 · Treatment Innovation
• TR-010 / PMID 42014858 · HDAC8 inhibitor + Venetoclax synergy in KMT2A-r AML regardless of TP53 (PDX, Leukemia) · 5/10 · Drug Development

CBC-Based Diagnostics & ML in Hematology — best score 7/10

• TR-004 / PMID 42013267 · APSevLM — LLM predicts acute pancreatitis severity (AUC 0.857, 500+ pts); CBC/hematological params key features · 7/10 · Diagnostics
• TR-007 / PMID 42013012 · Sysmex XR-9000 clinical validation vs XN-9100; excellent linearity r²>0.99 · 6/10 · Diagnostics
• TR-006 / PMID 42014714 · MCI subtypes degrade AD diagnostic ML models using routine CBC variables (ADNI cohort) · 7/10 · Diagnostics/Aging

Early Cancer Detection (remaining STANDARD)

• TR-011 / PMID 42012400 · ctHPV-DNA review in OPSCC; clearance predicts remission, persistence signals relapse months before imaging · 6/10 · Early Detection
• TR-012 / PMID 42011875 · Exosomal miRNA panel (AUC 0.90) predicts CRT response in rectal cancer; two-center validation (n=81) · 6/10 · Diagnostics
• TR-013 / PMID 42011810 · PlasDroplex — wash-free plasmonic EV detection; AUC 0.998 for lung cancer PD-L1 EVs (n=63) · 6/10 · Early Detection
• TR-014 / PMID 42011804 · ctDNA ddPCR BRAF correlated with PET-CT metabolic volume in melanoma (n=71, retrospective) · 5/10 · Diagnostics

AI/ML in Clinical Diagnostics & Imaging — best score 7/10

• TR-005 / PMID 42014463 · EXaCT-2 WES platform for comprehensive cancer genome profiling; 244 tumor/normal pairs validated · 7/10 · Genomics/Precision Medicine
• TR-018 / PMID 42014693 · Exhaled VOC + ML for Alzheimer's diagnosis; external validation accuracy 0.75 (n=285) · 6/10 · Diagnostics/Aging

Precision Oncology & Genomic Medicine — best score 7/10

• TR-005 / PMID 42014463 (see above — cross-topic)
• TR-015 / PMID 42014413 · Microbial metabolome review in hematologic malignancies; microbiome-targeted precision oncology pathway · 5/10 · Treatment Innovation
• TR-016 / PMID 42014456 · "Genomic medicine is failing most of humanity" (Nat Rev Nephrol); diversity equity commentary · 5/10 · Public Health 🟡 UNDERSERVED

GLP-1 / SGLT2 / Cardiometabolic — best score 6/10

• TR-017 / PMID 42014861 · Gut-brain axis + GLP-1 RAs review (Nat Rev Gastroenterol); vagus nerve as underexplored obesity target · 6/10 · Prevention
• TR-019 / PMID 42012088 · CRP/albumin ratio superior to CRP alone for coronary collateral circulation in CCS/CTO (n=123) · 5/10 · Diagnostics

Aging, Longevity & Population Health — best score 7/10

• TR-006 / PMID 42014714 (see above — cross-topic)
• TR-018 / PMID 42014693 (see above — cross-topic)
• TR-020 / PMID 42014786 · Transcranial vibrotactile stimulation (40/80 Hz) enhances cholinergic memory in mice · 3/10 LOW · Animal only

💡 UNSOLICITED FINDS

None identified this run. Sentinel scan (700 raw → 10 reviewed) yielded no new high-signal out-of-watchlist articles; all top sentinel hits overlapped with watchlist searches.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 11 articles
• Treatment Innovation: 5 articles
• Early Detection: 4 articles (2 HIGH)
• Genomics/Precision Medicine: 2 articles
• Public Health: 1 article
• Prevention: 1 article
• Drug Development: 1 article

By evidence maturity:

• Validated: 8
• Exploratory: 12
• Potentially Practice-Changing: 1 (MM consensus)
• Preprint: 0

By watchlist topic (reviewed / kept / highest score):

By source type: peer_reviewed: 22 | preprint: 0 Topics with zero 8+ articles this run: Hematologic malignancies, CBC/ML, AI/ML diagnostics, Precision oncology, GLP-1/SGLT2, Aging, Rare diseases

🔧 RUN NOTES

• Window expansion NOT triggered: 22 articles above threshold; no expansion to 48h required
• Rare disease topic sparse: Only 6 CRDT hits in window; 0 abstracts reviewed; flagged for possible 48h expansion consideration next run if pattern continues
• PMID 42014847 anomaly: Appeared as #1 result in 3 independent topic searches (CBC/ML, ctDNA, aging); abstract failed to parse; deferred as high-priority unreviewed to next run
• Cross-topic efficiency: Several articles scored under multiple topics (42014714, 42014693, 42014463); counted once in article total
• Previous run deferred PMIDs (42009662, 42009577, 42008449, 42008246) from pre-window date; not re-reviewed; cleared from active deferred queue
• Alert cap: 2 HIGH articles — both alerts sent (under 5-per-run cap)
• No rolling 7-day state yet available for persistent drought tracking by topic (state.json has only last_run)