📅 PUBMED DAILY TRIAGE — 2026-04-20

Window: 2026-04-19T09:00:00Z → 2026-04-20T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~70 candidates | Candidates fully evaluated: 18 High priority: 3 | Standard: 12 | Low/archive: 3 | Unsolicited finds: 0 Run status: SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Precision Oncology & Genomic Medicine

TR-2026-04-20-001 / PMID 42001218 · Prioritizing context-specific genetic risk mechanisms in 11 solid cancers · 9/10 · 🔴 EARLY_CANCER_DETECTION

JNCI paper applying novel CT-FM computational framework to identify specific cell types and regulatory elements driving cancer susceptibility across 11 tumors (avg n~48K cases); 489 regulatory quadruplets constructed — highest-quality genomics paper of the day.

Aging, Longevity & Population Health

TR-2026-04-20-002 / PMID 42002429 · Temporal and demographic trends in infective gastroenteritis-related mortality, U.S. adults 1999-2023 · 8/10 · 🟡 UNDERSERVED_POPULATION

25-year nationwide CDC analysis of 304,378 deaths demonstrates adults ≥85 have 23× higher mortality than baseline (AAMR 23.22) and NH American Indians bear highest race-stratified burden; large-scale equity evidence with actionable public health implications.

Rare Diseases with High Unmet Need

TR-2026-04-20-003 / PMID 42001281 · NGS reveals genetic heterogeneity in MEFV-negative/heterozygous familial Mediterranean fever (n=320) · 8/10 · 🟢 NEAR_TERM_IMPLEMENTABLE

Comprehensive NGS (MEFV + 18 autoinflammatory genes) increased diagnostic yield by 34% in FMF patients who tested negative on standard 16-variant screening; 45/320 patients carried non-MEFV gene variants (TNFRSF1A, NOD2, PSTPIP1), revealing oligogenic mechanisms — clinically actionable today.

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic Malignancies

• TR-2026-04-20-004 / PMID 42002230 · Brexu-cel real-world r/r MCL Austria n=33, ORR 95.9%, 2yr OS 76.8%; neutrophil count at lymphodepletion predicts ICANS · 7/10 · Treatment Innovation
• TR-2026-04-20-005 / PMID 42002058 · CLL therapy-driven clonal dynamics review (Karolinska/San Raffaele); BTK/PLCG2 mutations, CAR-T resistance, scRNA-seq positioning · 6/10 · Genomics/Precision Medicine
• TR-2026-04-20-006 / PMID 42001307 · S1PR3 expression predicts B-ALL 3-yr relapse independently, AUC 0.887, n=285 · 6/10 · Diagnostics
• TR-2026-04-20-008 / PMID 42001309 · Suspicious immunofixation bands (SfMB) in monoclonal gammopathy workup: none progressed to overt disease at 6yr; nomenclature reform proposed · 5/10 · Diagnostics
• TR-2026-04-20-009 / PMID 42001290 · NXPE3 proteomics in childhood ALL (n=15, DISCOVERY ONLY); CNS infiltration biomarker candidate · 5/10 · Diagnostics

Early Cancer Detection / Liquid Biopsy

• TR-2026-04-20-010 / PMID 42001282 · Serum exosome miRNAs in acral melanocytic tumors; 69 differentially expressed miRNAs; underrepresented rare skin cancer · 5/10 · Early Detection

AI/ML in Clinical Diagnostics

• No results in CRDT window today.

Novel Therapeutics (Immunotherapy / CAR-T)

• TR-2026-04-20-013 / PMID 42002344 · α-glucan (GFI-21α) from Grifola frondosa: in vivo tumor suppression via CD8+/IFN-γ, beats lentinan comparator (PRECLINICAL, mouse) · 4/10 · Drug Development
• TR-2026-04-20-014 / PMID 42001524 · Triazolopyrimidine-imatinib hybrids for BCR-ABL1-resistant CML; off-target mechanism in K562 cells (IN VITRO) · 4/10 · Drug Development

Cardiometabolic / GLP-1 / SGLT2

• No results in CRDT window today.

Aging, Longevity & Population Health

• TR-2026-04-20-007 / PMID 42001296 · TCR repertoires across CVD/age-related diseases; first-in-class CVD-TCR database; Immunol Rev · 6/10 · Diagnostics
• TR-2026-04-20-011 / PMID 42001565 · VitD + resistance exercise RCT n=46 older women: null result — VitD adds nothing beyond exercise alone · 5/10 · Prevention
• TR-2026-04-20-012 / PMID 42001278 · Mediterranean vs Western diet → telomere length + hippocampal preservation in rats (PRECLINICAL, n=21) · 5/10 · Prevention
• TR-2026-04-20-015 / PMID 42001311 · COVID-19 vaccination does not alter CD4+/CD8+ counts in HIV+ South African women (n=40) · 5/10 · Public Health
• TR-2026-04-20-016 / PMID 42001299 · Frailty (mFI5) influences steroid treatment selection but NOT audiometric outcomes in SSNHL (n=185) · 5/10 · Diagnostics

💡 UNSOLICITED FINDS

None today. Sentinel scan (55 results, top 10 reviewed) was dominated by articles already captured in watchlist topic searches.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 7 · Treatment Innovation: 2 · Genomics/Precision Medicine: 2
• Public Health: 3 · Drug Development: 2 · Prevention: 3 · Early Detection: 1

By evidence maturity:

• Exploratory: 14 · Validated: 3 · Potentially Practice-Changing: 0

By watchlist topic (reviewed / kept / highest score):

By source type: peer_reviewed: 18 | preprint: 0

By priority flag:

• 🔴 EARLY_CANCER_DETECTION: 1
• 🟡 UNDERSERVED_POPULATION: 2
• 🟢 NEAR_TERM_IMPLEMENTABLE: 1
• ⚪ PROMISING_PRELIMINARY: 5
• ⬜ NONE: 9

Topics with zero 8+ articles: CBC/ML hematology (14-day drought), AI/ML clinical diagnostics, Cardiometabolic/GLP-1/SGLT2 (current window)

🔧 RUN NOTES

• No window expansion triggered: 18 articles kept (>5 threshold met)
• CBC/ML hematology drought continues: Zero results in 24hr CRDT window for 14th consecutive run. Broad search using full blood count + ML/AI/algorithm terms returned 0. Topics captured incidentally by hematology malignancy search may include borderline cases not yet indexed under CBC/ML terms.
• Zero topics (AI/ML, Cardiometabolic): Strict AND-conjunction queries return 0 in narrow 24hr CRDT window for fresh, not-yet-indexed records. Expanding to 48hr would likely recover results; no expansion triggered today as overall article count was adequate (18).
• Aging search capped at 10: 16 results returned; 6 not reviewed (PMIDs: 42001262, 42001257, 42001274, and 3 others). These are carried to next run.
• Sentinel scan: 55 results; top 10 reviewed; 4 non-overlapping PMIDs unreviewed (42002828, 42002150, 42002000, 42001622) — deferred to next run.
• 45 deferred PMIDs from 2026-04-19 PARTIAL_SUCCESS remain unprocessed. Recommended: dedicated catch-up pass in next available run slot.
• Article quality note: Several results this window came from Pakistan Journal of Pharmaceutical Sciences (42001282, 42001290) — valid but lower-tier venue; scored conservatively.
• Rolling 7-day topic performance (from state): CBC/ML hematology has produced 0 HIGH articles in 14 consecutive runs; cardiometabolic produced 0 HIGH in 7 days. Recommend periodic broader window for these topics (consider 48hr) or query refinement.