The PPTC7/BNIP3/NIX axis induces cGAS/STING-mediated senescence and augments CAR-T efficacy by repressing tumor-intrinsic mitophagy
Disrupting a cellular recycling process in myeloma cells makes them visible to CAR-T therapies, potentially overcoming current treatment resistance.
Targeting the PPTC7/BNIP3/NIX mitophagy axis in multiple myeloma triggers cGAS/STING-mediated cellular senescence, creating an immunogenic tumor microenvironment that augments CAR-T cell killing. This mechanism offers a potential combination strategy to overcome CAR-T therapy resistance in relapsed/refractory multiple myeloma.
What the study was
- Study design
- Preclinical in vitro + murine model
- Population
- Multiple myeloma cell lines and murine model
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Journal of Experimental & Clinical Cancer Research
Why it surfaced
Novel CAR-T sensitization mechanism in multiple myeloma (high unmet need post triple-class refractoriness); preclinical with in vivo confirmation.
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