📅 PUBMED DAILY TRIAGE — 2026-04-07 Window: 2026-04-06T09:00:00Z → 2026-04-07T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: ~85 | Candidates evaluated: 16 High priority: 2 | Standard: 9 | Low/archive: 5 | Unsolicited finds: 0 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Early cancer detection (liquid biopsy, ctDNA, cfDNA)
41941615 · Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test · 9/10 · Novel MethylScan platform achieves AUROC 0.938 for multicancer detection in 1,061 individuals (PNAS)
Hematologic malignancies
41943118 · The viral and host genomic landscape of human T-cell leukemia virus type I in Peru · 8/10 · First comprehensive HTLV-1 genomic characterization in South America reveals early oncogenic mutations and 13.4% mortality in underserved population
🟢⚪ STANDARD (5-7) — Top by Topic
Early cancer detection
41943016 · Composite proteomic and metabolomic plasma biomarkers for detection of colorectal, lung and ovarian cancers · 7/10 · Multi-omics MCED approach (Mol Cancer) 41943036 · Novel diagnostic model combining ProGRP and inflammatory biomarkers for early detection of lung cancer · 6/10 · Early Detection 41941932 · Methylated Septin9 as auxiliary biomarker for CRC diagnosis and monitoring · 5/10 · Diagnostics
Rare diseases with high unmet need
41942455 · ASO therapy rescues NOTCH2NLC GGC repeat expansion-induced genomic damage and senescence · 7/10 · First proof-of-concept ASO therapy for NIID (Nature Comms)
Precision oncology and genomic medicine
41942356 · Predictive value of insertion/deletion rate in gastric cancer treated with nivolumab + chemo · 6/10 · Genomics/Precision Medicine
Aging, longevity, and population health
41942023 · Geroprotective and anti-aging effects of metformin: AMPK activation to SASP suppression · 6/10 · Prevention
Novel therapeutics
41941588 · pRECIST: Response criteria guidelines for pancreatic cancer trials · 6/10 · Treatment Innovation 41942944 · Neoadjuvant ultrahypofractionated RT with SIB for glioblastoma (Phase I protocol) · 5/10 · Treatment Innovation
CBC-based diagnostics and ML in hematology
41939468 · ML prediction of severe myelosuppression in CRC chemotherapy using XGBoost/SHAP · 5/10 · Diagnostics
Cardiovascular-metabolic
41942673 · Transportation noise and CVD outcomes: systematic review and meta-regression · 5/10 · Public Health
AI/ML in clinical diagnostics
41939888 · Diagnostic nomogram for de novo metastatic RCC integrating immune-inflammatory biomarkers · 5/10 · Diagnostics
💡 UNSOLICITED FINDS
None this run — sentinel scan results fully covered by watchlist topic searches.
📊 TODAY'S BREAKDOWN
- By research category: Early Detection 4 | Diagnostics 4 | Treatment Innovation 3 | Genomics/Precision Med 2 | Drug Development 1 | Prevention 1 | Public Health 1 | Other 3
- By evidence maturity: Validated 8 | Exploratory 8 | Potentially Practice-Changing 0
- By watchlist topic:
- Hematologic malignancies: 10 reviewed / 4 kept / highest 8
- CBC/ML hematology: 5 reviewed / 2 kept / highest 5
- Early cancer detection: 10 reviewed / 5 kept / highest 9
- AI/ML diagnostics: 10 reviewed / 2 kept / highest 6
- Precision oncology: 10 reviewed / 2 kept / highest 7
- Novel therapeutics: 10 reviewed / 3 kept / highest 6
- CV-metabolic: 10 reviewed / 1 kept / highest 5
- Aging/longevity: 10 reviewed / 1 kept / highest 6
- Rare diseases: 10 reviewed / 1 kept / highest 7
- By source type: peer_reviewed 16 | preprint 0
- Topics with zero 8+ articles this run: CBC/ML hematology, AI/ML diagnostics, Precision oncology, Novel therapeutics, CV-metabolic, Aging/longevity, Rare diseases
🔧 RUN NOTES
- Monday CRDT window covering Sunday indexing batch — moderate yield as expected.
- CBC/ML topic improved: 5 candidates vs. 0 in previous runs. Persistent gap resolved.
- High-volume topics (precision oncology: 186, aging: 147, CV-metabolic: 139 raw results) were capped at 10 candidates per topic per spec.
- 3 articles had incomplete metadata due to API response truncation; scored conservatively as title-only (capped at 3).
- MethylScan paper (PMID 41941615) in PNAS is the standout find — cost-effective cfDNA methylome platform with strong multi-disease detection performance.