📅 PUBMED DAILY TRIAGE — 2026-04-05 Window: 2026-04-04 00:00 UTC → 2026-04-05 00:00 UTC (CRDT) Topics scanned: 10 | Articles reviewed: ~90 | Candidates evaluated: ~90 High priority: 2 | Standard: 12 | Low/archive: 6 | Unsolicited finds: 0 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic Malignancies
41935242 · TCF3::HLF-positive B-ALL: integrated clinical and molecular characterization of 34 cases · 8/10 · Largest molecular characterization of ultra-rare TCF3::HLF+ B-ALL; identifies RAS mutations (85.7%) and CD33 expression (79.4%) as actionable targets; 5-year OS 35.2% with allo-HSCT essential
Early Cancer Detection (Liquid Biopsy)
41933678 · ctDNA-based MRD detection and clinical utility in early-stage cancer: SR/meta-analysis · 8/10 · Meta-analysis confirming high specificity and strong prognostic value of ctDNA MRD detection across early-stage cancers — gold-standard study design for this critical domain
Topics with No HIGH Finds Today:
- CBC-based diagnostics and ML in hematology: Best candidate scored 6/10
- AI/ML in clinical diagnostics: Best candidate scored 7/10 (Decipher-MR foundation model)
- Precision oncology: Best candidate scored 6/10
- Novel therapeutics (immunotherapy/CAR-T): Best candidate scored 7/10 (TP53 & CAR-T, double refractory CLL)
- Cardiovascular-metabolic: Best candidate scored 5/10
- Aging/longevity: Best candidate scored 5/10
- Rare diseases: Best candidate scored 7/10 (Vosoritide SR/MA)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies
- 41934060 · Current Treatment of Double Refractory CLL: Focus on Novel Drugs · 7/10 · Treatment Innovation
- 41935222 · TP53 alterations impact on CAR-T outcomes in pediatric B-ALL · 7/10 · Genomics/Precision Medicine
- 41934567 · Targeting PI3Kδ for lymphoma treatment: review · 5/10 · Drug Development
- 41934430 · miRNA biomarkers for chemoresistance in DLBCL · 5/10 · Diagnostics
Early Cancer Detection
- 41933456 · cfDNA fragmentation + methylation for multi-cancer detection · 7/10 · Early Detection
- 41934036 · ctDNA dynamics during neoadjuvant therapy · 6/10 · Early Detection
AI/ML in Clinical Diagnostics
- 41935229 · Decipher-MR: vision-language foundation model for 3D MRI · 7/10 · Diagnostics
- 41934741 · AI prediction of neoadjuvant response in breast cancer · 6/10 · Diagnostics
Precision Oncology
- 41934464 · IASLC Consensus: definitive RT in stage IV NSCLC · 6/10 · Treatment Innovation
Rare Diseases
- 41934413 · Vosoritide in achondroplasia: SR/meta-analysis · 7/10 · Treatment Innovation
- 41934608 · Gene replacement for Christianson syndrome (preclinical) · 5/10 · Treatment Innovation
CBC-based Diagnostics
- 41933481 · ML-based CBC interpretation for hematologic malignancy screening · 6/10 · Diagnostics
💡 UNSOLICITED FINDS
None — sentinel scan results overlapped entirely with watchlist topic results.
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation 5 | Diagnostics 4 | Early Detection 3 | Genomics/Precision Medicine 2 | Drug Development 2 | Other 4
- By evidence maturity: Validated 8 | Exploratory 6 | Potentially Practice-Changing 0
- By watchlist topic: Hematologic malignancies 7 reviewed/5 kept/8 highest | Liquid biopsy 7/3/8 | AI/ML diagnostics 10/2/7 | CAR-T/immunotherapy 10/2/7 | Precision oncology 10/1/6 | CBC+ML 10/1/6 | Rare diseases 10/2/7 | Cardio-metabolic 10/0/5 | Aging 10/0/5
- By source type: peer_reviewed 14 | preprint 0
- Topics with zero 8+ articles: CBC diagnostics, AI/ML diagnostics, Precision oncology, Immunotherapy/CAR-T, Cardiovascular-metabolic, Aging/longevity, Rare diseases
🔧 RUN NOTES
- Sunday CRDT window yielded moderate volume; lower than weekday average
- No window expansion needed (>5 relevant records found)
- No truncation applied
- Sentinel scan (154 raw results) overlapped heavily with topic-specific searches; no unique high-signal unsolicited finds
- Multiple topic fetches truncated at 50KB; some article metadata inferred from search context
- No deferred PMIDs for next run