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‹ Thu · 2 Apr 2026
Standard addition

Efficacy of Glucagon-Like Peptide-1 Receptor Agonists for Psychological Well-Being and Depressive Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Weight-loss drugs don't appear to worsen depression or psychological well-being in people who take them, addressing important safety concerns for these widely used medications.

This systematic review and meta-analysis of RCTs examines the effect of GLP-1 receptor agonists on depression and psychological well-being. The findings address important safety questions about neuropsychiatric effects of these widely prescribed medications.

What the study was

Study design
Systematic review and meta-analysis of RCTs
Population
Patients on GLP-1 RAs across trials
Category
Treatment Innovation
Maturity
Validated
Journal
Human Psychopharmacology

Why it surfaced

SR/MA of GLP-1RA neuropsychiatric effects from RCTs. Addresses safety concern for widely used drugs.

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