📅 PUBMED DAILY TRIAGE — 2026-03-31 Window: 2026-03-30T09:00:00Z → 2026-03-31T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: ~90 | Candidates evaluated: 17 High priority: 6 | Standard: 10 | Low/archive: 0 | Unsolicited finds: 1 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Rare diseases with high unmet need
- PMID 41912932 · Biallelic variants in RNU2-2 cause the most prevalent known recessive NDD · 9/10 · Landmark Nat Genet discovery: recessive RNU2-2 mutations account for ~10% of diagnosable recessive NDD families
- PMID 41912933 · Biallelic variants in RNU2-2 cause a remarkably frequent DEE · 9/10 · Companion paper delineating clinical phenotype + proposing U2-2/U2-1 diagnostic biomarker
- PMID 41912934 · Systematic analysis of snRNA genes reveals frequent RNU2-2 variants in DEE · 8/10 · Third concurrent paper establishing snRNA genes as a major non-coding disease gene class
Hematologic malignancies
- PMID 41912408 · Phase 3 FLAIR trial QoL: ibrutinib-rituximab vs FCR in untreated CLL · 8/10 · Patient-reported outcomes from a practice-defining Phase 3 CLL trial
Early cancer detection
- PMID 41912411 · Measuring screening benefit in the MCED era (JNCI) · 8/10 · Framework for evaluating multi-cancer early detection tests from leading screening researchers
Precision oncology and genomic medicine
- PMID 41912930 · Genome-wide fine-mapping improves causal variant identification (Nat Genet) · 8/10 · Major statistical genetics advance from Visscher/Wray group
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic malignancies
- PMID 41912510 · Mutant RPS15 drives B cell malignancy via oxidative stress · 6/10 · Drug Development
- PMID 41912486 · Targeting LAPTM5 enhances AML sensitivity to cytarabine · 5/10 · Drug Development
- PMID 41904949 · Ketogenic diets enhance therapy in FLT3-ITD AML · 5/10 · Treatment Innovation (deferred recovery)
Cardiovascular-metabolic
- PMID 41912265 · SURPASS-SWITCH subgroup: dulaglutide-to-tirzepatide switch in T2D · 6/10 · Treatment Innovation
- PMID 41912427 · GLP-1 RA cardioprotection in autoimmune rheumatic diseases · 5/10 · Treatment Innovation
Early cancer detection
- PMID 41912058 · cfDNA vs endomyocardial biopsy in transplant monitoring · 5/10 · Diagnostics
- PMID 41912077 · Immunosensors for ovarian cancer detection · 5/10 · Early Detection
Novel therapeutics
- PMID 41904892 · Exosomal PD-L1 in HCC: immune evasion and targeting · 5/10 · Treatment Innovation (deferred recovery)
Aging, longevity, and population health
- PMID 41905169 · Epigenetic age acceleration and motor impairment in Parkinson's · 5/10 · Diagnostics (deferred recovery)
CBC/hematology diagnostics: No qualifying articles this run (best candidates scored <5)
AI/ML diagnostics: No qualifying articles this run (best candidates scored <5)
💡 UNSOLICITED FINDS
- PMID 41911535 · PEG-selenium nanoparticles for ultrasensitive NT-proBNP POC detection · 5/10 · Novel cardiac diagnostic tech
- PMID 41912485 · Blood proteomic biomarkers predicting psychosis transition · 5/10 · Mental health biomarker discovery
📊 TODAY'S BREAKDOWN
- By research category: Genomics/Precision Medicine (4) | Treatment Innovation (4) | Diagnostics (4) | Drug Development (2) | Early Detection (2) | Prevention (1)
- By evidence maturity: Validated (5) | Exploratory (11) | Potentially Practice-Changing (1)
- By watchlist topic: Rare disease (3 HIGH) | Hematologic malignancies (1 HIGH, 3 STD) | Early detection (1 HIGH, 2 STD) | Precision oncology (1 HIGH) | CV-metabolic (2 STD) | Immunotherapy (1 STD) | Aging (1 STD) | CBC/ML hema (0) | AI diagnostics (0)
- By source type: peer_reviewed 17 | preprint 0
- Topics with zero 8+ articles: CBC diagnostics, AI/ML diagnostics, Novel therapeutics, Cardiovascular-metabolic, Aging
🔧 RUN NOTES
- Deferred PMIDs: 26 deferred from 2026-03-30 run recovered; 3 incorporated (41904949, 41905169, 41904892); remainder off-topic or below threshold
- Highlight: Three simultaneous Nature Genetics papers on RNU2-2 represent a landmark rare disease discovery — the most prevalent known recessive NDD gene. This is a major event in the rare disease/genomic medicine space.
- Zero high-priority rolling: CBC diagnostics and AI/ML diagnostics have produced zero high-priority articles for 2 consecutive runs
- No window expansion needed (17 relevant articles found)
- No truncation or partial failures this run