📅 PUBMED DAILY TRIAGE — 2026-03-27

Window: 2026-03-26T09:00:00Z → 2026-03-27T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~50 (abstract-level) | Kept: 10 High priority: 1 | Standard: 8 | Low/archive: 1 | Unsolicited finds: 0 Run status: SUCCESS

🔴🟠 HIGH PRIORITY

TR-2026-03-27-001 · PMID 41887986 · In vivo CAR T cell engineering: design principles and open questions · 6/10 🟠 NOVEL_TREATMENT

Review from Dana-Farber/MIT surveys viral and nonviral approaches to directly reprogram T cells inside patients, bypassing costly ex vivo manufacturing — early clinical studies show safety and therapeutic activity, with potential to democratize CAR-T access for hematologic malignancies.

🟢⚪ STANDARD

TR-2026-03-27-002 · PMID 41887957 · Efficacy of preoperative GLP-1 receptor agonists on the perioperative outcomes of bariatric surgery: a systematic review and meta-analysis · 7/10 🟢 NEAR_TERM_IMPLEMENTABLE

Meta-analysis (n=5,461, 10 studies): preoperative GLP-1 RAs are safe but yield only modest preoperative weight loss, without significant improvement in postoperative outcomes or comorbidity remission — important practical guidance amid widespread GLP-1 prescribing. | Cardiovascular-metabolic: GLP-1

TR-2026-03-27-003 · PMID 41888063 · Enhancing Diagnostic Precision in Malignant Hematological Disorders Through Risk Factor Analysis for High-Quality Bone Marrow Aspirate · 6/10 🟢 NEAR_TERM_IMPLEMENTABLE

Retrospective cohort (n=875): advanced age and low CBC parameters (Hb, platelets, WBC) independently predict suboptimal BMA quality in AML and MDS — actionable predictors for procedural planning. | Hematologic malignancies / CBC diagnostics

TR-2026-03-27-004 · PMID 41887965 · Influence of CT reconstruction algorithms on coronary artery calcium scores and reader agreement · 6/10 🟢 NEAR_TERM_IMPLEMENTABLE

Validation study (n=120): deep learning CT reconstruction (DLIR-H) achieves κ=0.994 inter-reader agreement for CACS vs κ=0.976 for FBP, eliminating systematic reader bias — clinically applicable on current-generation scanners. | AI/ML in diagnostics / Cardiovascular-metabolic

TR-2026-03-27-005 · PMID 41888053 · Primary brainstem lymphoma: clinical characteristics, treatment methods, and prognostic factors of 56 patients · 6/10 🟡 UNDERSERVED_POPULATION

Largest single-center PBSL cohort (n=56): HD-MTX achieves 70.5% ORR, median OS 30 months; age ≥60 dominant adverse prognostic factor (HR 3.086) — fills a critical evidence gap for this ultra-rare CNS lymphoma. | Hematologic malignancies (lymphoma)

TR-2026-03-27-006 · PMID 41887926 · Enhanced magnetic hyperthermia using anti-PD-L1 antibody-conjugated magnetoliposomes in a murine bladder cancer model · 5/10 ⚪ PROMISING_PRELIMINARY

Murine study (n=5/group): α-PD-L1@magnetoliposome single-session hyperthermia achieves 4/5 complete regressions vs 0/5 for standalone hyperthermia at same temperature, via CD8+ T cell recruitment. | Novel therapeutics (immunotherapy)

TR-2026-03-27-007 · PMID 41887960 · Follicular and follicle center-cell lymphomas: A family between kinship and diversity · 5/10 ⬜ NONE

WHO-HAEM5 classification update: grades 1-3A merged into "classic FL," grade 3B renamed "follicular large B-cell lymphoma," multiple BCL2-R-negative variants newly recognized — impacts pathology reporting and trial eligibility. | Hematologic malignancies (lymphoma)

TR-2026-03-27-008 · PMID 41887936 · Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis · 5/10 ⚪ PROMISING_PRELIMINARY

Cross-sectional study (n=62): salivary MV methylome (1,196 DMRs, AUC>0.9) and bacterial outer membrane vesicles (AUC>0.89) distinguish stage III/IV periodontitis — advances salivary liquid biopsy methodology with broader diagnostic potential. | Early cancer detection (liquid biopsy)

TR-2026-03-27-009 · PMID 41888049 · Gut Luminal Exosomes in Young and Old Mice: Multi-Omic Characteristics and Regulation of Gut Permeability · 5/10 ⚪ PROMISING_PRELIMINARY

Mouse study: LFEs from aged animals transfer gut barrier dysfunction and insulin resistance to young recipients; multi-omics reveals age-specific exosomal cargo linked to metabolic decline — novel aging biology mechanism. | Aging, longevity, and population health

💡 UNSOLICITED FINDS

None. Sentinel scan reviewed (220 hits); all high-signal results overlapped with watchlist-matched articles already captured.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 3 (BMA quality, CACS DLIR, salivary MV methylome)
• Treatment Innovation: 3 (in vivo CAR-T, PBSL outcomes, GLP-1 pre-bariatric)
• Drug Development: 2 (immunotherapy+hyperthermia nanoparticle, ASO in rare disease)
• Prevention: 1 (gut exosome-aging model)
• Other/Editorial: 1 (ASO rare disease — low)

By evidence maturity:

• Exploratory: 6
• Validated: 4
• Potentially Practice-Changing: 0

By watchlist topic (records may span multiple):

• Hematologic malignancies: 3 (PMID 41888063, 41888053, 41887960)
• Novel therapeutics (immunotherapy/CAR-T): 2 (PMID 41887986, 41887926)
• AI/ML in clinical diagnostics: 1 (PMID 41887965) + overlap
• Cardiovascular-metabolic (GLP-1): 2 (PMID 41887957, 41887965)
• Early cancer detection (liquid biopsy): 1 (PMID 41887936)
• Aging/longevity: 1 (PMID 41888049)
• Rare diseases: 1 (PMID 41887927)
• CBC/ML hematology: 1 (PMID 41888063, cross-match)
• Precision oncology: 0 (top hits captured under other topics)

By source type: peer_reviewed: 10 | preprint: 0 By access level: Abstract only: 10

🔧 RUN NOTES

• Window expansion: NOT triggered. 10 articles identified in 24h window (≥5 threshold met).
• Truncation: Not triggered. Per-topic caps applied; records selected for highest relevance signal.
• Partial failures: None. All 10 topics + sentinel scan returned results.
• Precision oncology/genomic medicine: 53 hits; top results reviewed — all mapped to already-captured watchlist articles (liquid biopsy, CAR-T). Zero net-new records.
• CBC/ML hematology: 24 hits; top results reviewed — primarily blood disorder diagnostics/imaging AI, not CBC-specific ML pipeline. PMID 41888063 cross-matched here from hematologic malignancies topic.
• Sentinel scan (220 hits): All high-signal top-10 results overlapped with watchlist articles already captured. 0 unsolicited finds retained.
• CRDT indexing lag: Consistent with prior runs — window fully covered; no expansion needed.
• Prior fingerprint deduplication: Zero duplicates (today's PMIDs 41887926–41888063, all above prior max of 41881829).
• All records abstract-only. No PMC full text reviewed this run.