Effects of Nutritional Supplement Intake on Pregnancy Outcomes in Overweight and Obese Women: A Systematic Review and Meta-Analysis
Inositol and omega-3 supplements reduce serious pregnancy complications in overweight women—practical, low-risk options backed by clinical trials.
This meta-analysis of 19 RCTs (3,482 overweight/obese pregnant women) finds that inositol and omega-3 supplementation have beneficial pregnancy outcomes (reduced preterm birth, preeclampsia, macrosomia), while probiotic supplementation significantly increased preterm birth risk. These findings provide directly implementable clinical guidance for this high-prevalence maternal subgroup.
What the study was
- Study design
- Systematic review and meta-analysis of 19 RCTs (n=3,482)
- Population
- Overweight/obese pregnant women (BMI ≥25), n=3,482 pooled
- Sample size
- 3482
- Category
- Prevention
- Maturity
- Validated
- Journal
- Journal of Obstetrics and Gynaecology Research
Why it surfaced
High-quality meta-analysis with actionable clinical guidance for obese pregnant women; probiotic harm signal is particularly significant. Maternal obesity is a high-prevalence, underserved population.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.